Lusianthridin - ≥98% , CAS No.87530-30-1

CAS: 87530-30-1 Cat. No.: L651857 Molecular Weight: 242.27 PubChem CID: 442702

GRADE & PURITY ≥98%

Synonyms

DTXSID50331917 | BDBM246496 | 2,5-Dihydroxy-7-methoxy-9,10-dihydrophenanthrene (14) | CHEBI:28678 | FS-7984 | 4,7-Dihydroxy-2-methoxy-9,10-dihydrophenanthrene | SCHEMBL4743850 | 7-methoxy-9,10-dihydrophenanthrene-2,5-diol | Q27103833 | HY-121418 | Lusiant

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Lusianthridin, a pure compound from Dendrobium venustum , have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling.

In Vitro

Lusianthridin (0-100 μM) inhibits cell viability at concentrations greater than 50 μM in both H460 and H292 cells. Lusianthridin significantly reduces the CSC populations in both H460 and H292 cells of the CSC spheres, with a significant decrease in the size of the H460 CSC spheres by approximately 10%, 63%, and 77% at day 3 at concentration 5, 10, and 20 μM Lusianthridin, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: The human non-small cell lung cancer cell lines, NCI-H460, and NCI-H292 cells.\n0-100 μM. Concentration: 0-100 μM. Incubation Time: 24 h. Result: Caused a significant reduction in terms of cell viability at concentrations greater than 50 μM in both H460 and H292 cells.

Form:Solid

Specifications

Synonyms

DTXSID50331917 | BDBM246496 | 2, 5-Dihydroxy-7-methoxy-9, 10-dihydrophenanthrene (14) | CHEBI:28678 | FS-7984 | 4, 7-Dihydroxy-2-methoxy-9, 10-dihydrophenanthrene | SCHEMBL4743850 | 7-methoxy-9, 10-dihydrophenanthrene-2, 5-diol | Q27103833 | HY-121418 | Lusiant

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Lusianthridin, a pure compound from Dendrobium venustum , have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling.

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: COC1=CC2=C(C3=C(CC2)C=C(C=C3)O)C(=C1)O
• IUPAC Name: 7-methoxy-9,10-dihydrophenanthrene-2,5-diol
• InChIKey: RDKDIPDDUFMMMT-UHFFFAOYSA-N
• INCHI: 1S/C15H14O3/c1-18-12-7-10-3-2-9-6-11(16)4-5-13(9)15(10)14(17)8-12/h4-8,16-17H,2-3H2,1H3
• Isomeric SMILES: COC1=CC2=C(C3=C(CC2)C=C(C=C3)O)C(=C1)O
• Alternate CAS: 87530-30-1
• PubChem CID: 442702
• MeSH Entry Terms: 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene;lusianthridin
• Molecular Weight: 242.27

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Phenanthrenes and derivatives
      • Subclass Hydrophenanthrenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Phenanthrenes and derivatives
• Subclass: Hydrophenanthrenes
• Intermediate Tree Nodes: Not available
• Direct Parent: Hydrophenanthrenes
• Alternative Parents: Naphthols and derivatives Anisoles Alkyl aryl ethers 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Hydrophenanthrene - 1-naphthol - Naphthalene - Anisole - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - Ether - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as hydrophenanthrenes. These are a phenanthrene derivative where at least one ring CC bond is substituted by hydrogenation.
• External Descriptors: dihydrophenanthrene

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

Discover Target: PTGS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

Discover Target: PTGS2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

RAW264.7 (28094 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ileum (29 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Molecular Weight: 242.270 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 242.094 Da
• Monoisotopic Mass: 242.094 Da
• Topological Polar Surface Area: 49.700 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 293.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1