LY466195 - Moligand™ , Antagonist of GluK1, CAS No.L611669, Antagonist of GluK1

CAS: L611669 Cat. No.: L611669 PubChem CID: 10168249

GRADE & PURITY Moligand™

Synonyms

LY 466195;LY-466195

Storage

Room temperature

Specifications

Synonyms

LY 466195;LY-466195

Specifications & Purity

Moligand™

Storage

Room temperature

Grade

Moligand™

Action Type

ANTAGONIST

Mechanism of action

Antagonist of GluK1

Names and Identifiers

• Canonical Smiles: OC(=O)C1NCC2C(C1)CC(CC2)CN1CC(CC1C(=O)O)(F)F
• IUPAC Name: 6-[(2-carboxy-4,4-difluoropyrrolidin-1-yl)methyl]-decahydroisoquinoline-3-carboxylic acid
• InChIKey: OXQXJYQSWZFDBB-UHFFFAOYSA-N
• INCHI: 1S/C16H24F2N2O4/c17-16(18)5-13(15(23)24)20(8-16)7-9-1-2-10-6-19-12(14(21)22)4-11(10)3-9/h9-13,19H,1-8H2,(H,21,22)(H,23,24)
• Isomeric SMILES: C1CC2CNC(CC2CC1CN3CC(CC3C(=O)O)(F)F)C(=O)O
• PubChem CID: 10168249

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Proline and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Proline and derivatives
• Alternative Parents: Alpha amino acids Piperidinecarboxylic acids Pyrrolidine carboxylic acids N-alkylpyrrolidines Dicarboxylic acids and derivatives Trialkylamines Amino acids Dialkylamines Carboxylic acids Azacyclic compounds Organofluorides Organic oxides Hydrocarbon derivatives Carbonyl compounds Alkyl fluorides
• Molecular Framework: Aliphatic heteropolycyclic compounds
• Substituents: Proline or derivatives - Alpha-amino acid - Piperidinecarboxylic acid - Pyrrolidine carboxylic acid - Pyrrolidine carboxylic acid or derivatives - Dicarboxylic acid or derivatives - Piperidine - N-alkylpyrrolidine - Pyrrolidine - Amino acid - Tertiary aliphatic amine - Tertiary amine - Carboxylic acid - Secondary aliphatic amine - Azacycle - Organoheterocyclic compound - Secondary amine - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Organic oxygen compound - Alkyl fluoride - Carbonyl group - Organic oxide - Hydrocarbon derivative - Alkyl halide - Organic nitrogen compound - Amine - Aliphatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as proline and derivatives. These are compounds containing proline or a derivative thereof resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

GRIK1 Tclin Glutamate receptor ionotropic, kainate 1 (0 Activities)

Discover Target: GRIK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)