Velzatinib(M4205) - Moligand™,≥99% , CAS No.2590556-80-0

CAS: 2590556-80-0 Cat. No.: M650715 Molecular Weight: 508.62 PubChem CID: 155587867

GRADE & PURITY Moligand™, ≥99%

Synonyms

[4-(Methyl-1H-pyrazol-4-yl)-benzyl] -(6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a] pyridin-3-yl]-pyrimidin-4-yl]-amine | MS-29449 | compound 32 [PMID: 36728508] | K3R | M4205 | M-4205 | Y6UHU32G5Z | GTPL11510 | 4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyra

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

M4205 is a c-KIT inhibitor, with an IC 50 of 10 nM for c-KIT V654A. M4205 has high activity on c-KIT mutations in exon 11, 13, 17.

Form:Solid

IC50& Target:c-KIT

Specifications

Synonyms

[4-(Methyl-1H-pyrazol-4-yl)-benzyl] -(6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1, 2-a] pyridin-3-yl]-pyrimidin-4-yl]-amine | MS-29449 | compound 32 [PMID: 36728508] | K3R | M4205 | M-4205 | Y6UHU32G5Z | GTPL11510 | 4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyra

Specifications & Purity

Moligand™, ≥99%

Biochemical and Physiological Mechanisms

Velzatinib (M4205) is a multi-target inhibitor for PDGFRB, PDGFRA, CSF1R, c-Kit, FLT3, and LCK, with an IC50s of 2.6, 50, 5.5, 44, 141 and 141 nM, respectively. Velzatinib exhibits antitumor efficacy in xenograft mouse models.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CN1C=C(C=N1)C2=CC=C(C=C2)CNC3=NC=NC(=C3)C4=CN=C5N4C=CC(=C5)OCCCN6CCCC6
• IUPAC Name: N-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine
• InChIKey: LVMAULGVWBINFP-UHFFFAOYSA-N
• INCHI: 1S/C29H32N8O/c1-35-20-24(18-34-35)23-7-5-22(6-8-23)17-30-28-16-26(32-21-33-28)27-19-31-29-15-25(9-13-37(27)29)38-14-4-12-36-10-2-3-11-36/h5-9,13,15-16,18-21H,2-4,10-12,14,17H2,1H3,(H,30,32,33)
• Isomeric SMILES: CN1C=C(C=N1)C2=CC=C(C=C2)CNC3=NC=NC(=C3)C4=CN=C5N4C=CC(=C5)OCCCN6CCCC6
• Alternate CAS: 2590556-80-0
• PubChem CID: 155587867
• Molecular Weight: 508.62

Chemical and Physical Properties

• Solubility: DMSO : 11.11 mg/mL (21.84 mM; ultrasonic and warming and heat to 66°C)
• Molecular Weight: 508.600 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 508.27 Da
• Monoisotopic Mass: 508.27 Da
• Topological Polar Surface Area: 85.400 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 715.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1