Methscopolamine - 10mM in DMSO , Muscarinic acetylcholine receptor M1 antagonist, CAS No.155-41-9, Muscarinic acetylcholine receptor M1 antagonist

CAS: 155-41-9 Cat. No.: M408775 Molecular Weight: 398.29 EC Number: 205-844-5 PubChem CID: 5459110

GRADE & PURITY 10mM in DMSO

Synonyms

(1α,​2β,​4β,​5α,​7β)​-7-​[(2S)​-​3-​hydroxy-​1-​oxo-​2-​phenylpropoxy]​-​9,​9-​dimethyl-3-​oxa-​9-​azoniatricyclo[3.3.1​.02,​4]​nonane, bromide (1:1)​

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Methscopolamine is a muscarinic acetylcholine receptor blocker.
In vitro

In vivo

Cell Data

cell lines：A375, 22RV1 and T474 cells

Concentrations：

Incubation Time：

Powder Purity:≥95%

Specifications

Synonyms

(1α, ​2β, ​4β, ​5α, ​7β)​-7-​[(2S)​-​3-​hydroxy-​1-​oxo-​2-​phenylpropoxy]​-​9, ​9-​dimethyl-3-​oxa-​9-​azoniatricyclo[3.3.1​.02, ​4]​nonane, bromide (1:1)​

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Methscopolamine is a muscarinic acetylcholine receptor blocker.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Mechanism of action

Muscarinic acetylcholine receptor M1 antagonist

Names and Identifiers

• Isomeric SMILES: C[N+]1([C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4)C.[Br-]
• PubChem CID: 5459110
• Molecular Weight: 398.29

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 30 mg/mL (100.21 mM); Water: Insoluble; Ethanol: Insoluble
• Specific Rotation[α]: -24°C

References

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2. Song Changgeng, Zhao Jingjing, Hao Jianmin, Mi Dan, Zhang Jiajia, Liu Yingying, Wu Shengxi, Gao Fang, Jiang Wen.  (2023)  Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus.  Cell Death Discovery,  9  (1): (1-18).  [PMID:37142587] [10.1038/s41420-023-01445-7]

3. Fankai Gao, Rui Chen, Shuo Li, An Li, Bo Bai, Rulin Mi, Guofang Xue.  (2023)  (+)-Borneol exerts neuroprotective effects via suppressing the NF-κB pathway in the pilocarpine-induced epileptogenesis rat model.  BRAIN RESEARCH,      [PMID:37127175] [10.1016/j.brainres.2023.148382]

4. Huijie Huangfu, Xugeng Guo, Ning Li, Ye Xiong, Yafei Huang, Jinglai Zhang, Li Wang.  (2023)  A smart composite coating with self-reporting and self-healing functions to enhance corrosion protection for magnesium alloys.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2023.107598]

5. Dai Jie, Shen Hai-lin, Li Jia, Zhou Yong, Dong Zheng-xie, Zhu Xiang-yang.  (2024)  Gastrodin Attenuates Neuroinflammation and Injury in Young Rats with LiCl/Pilocarpine-Induced Status Epilepticus.  BIOCHEMICAL GENETICS,      [PMID:39570508] [10.1007/s10528-024-10971-7]

6. Yang Yu, Li Xingchang, Gong Shuxian, Sui Lisen, Liu Jian, Yu Fangjun, Zhang Tianpeng.  (2025)  E4BP4-Driven Circadian SLC6A1 Expression Governs Tiagabine Chronoefficacy in Temporal Lobe Epilepsy.  MOLECULAR NEUROBIOLOGY,  63  (1): (242).  [PMID:41335220] [10.1007/s12035-025-05498-w]