Methylenediphosphonic acid（MDP） - ≥97% , CAS No.1984-15-2

CAS: 1984-15-2 Cat. No.: M132702 Molecular Weight: 176.00 Beilstein Registry Number: 1(4)3071 EC Number: 217-851-0

GRADE & PURITY ≥97%

Synonyms

MDP | Acide medronique (INN-French) | Methylene bis-phosphonic acid | 73OS0QIN3O | HY-108309 | MEDRONIC ACID | STL302043 | CAS-1984-15-2 | DTXCID6025696 | EINECS 217-851-0 | Methylene-1,1-bisphosphonic acid | NCGC00037856-01 | MEDRONIC ACID [MI] | Medrona

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Methylenediphosphonic acid can be used as a precursor in the synthesis of: Mesoporous aluminum organophosphonate in the presence of alkyltrimethylammonium as a surfactant. Tetraester of methylenediphosphonic acids which are used as metal ion extractants for actinides in all oxidation states.

Specifications

Synonyms

MDP | Acide medronique (INN-French) | Methylene bis-phosphonic acid | 73OS0QIN3O | HY-108309 | MEDRONIC ACID | STL302043 | CAS-1984-15-2 | DTXCID6025696 | EINECS 217-851-0 | Methylene-1, 1-bisphosphonic acid | NCGC00037856-01 | MEDRONIC ACID [MI] | Medrona

Specifications & Purity

≥97%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 504752734
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504752734
• Canonical Smiles: C(P(=O)(O)O)P(=O)(O)O
• IUPAC Name: phosphonomethylphosphonic acid
• InChIKey: MBKDYNNUVRNNRF-UHFFFAOYSA-N
• INCHI: 1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)
• Isomeric SMILES: C(P(=O)(O)O)P(=O)(O)O
• WGK Germany: 3
• RTECS: SZ9138000
• Molecular Weight: 176.00
• Beilstein: 1(4)3071
• Reaxy-Rn: 1708494
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1708494&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Organic phosphonic acids and derivatives
      • Subclass Bisphosphonates

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Organic phosphonic acids and derivatives
• Subclass: Bisphosphonates
• Intermediate Tree Nodes: Not available
• Direct Parent: Bisphosphonates
• Alternative Parents: Organic phosphonic acids Organopnictogen compounds Organophosphorus compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Bisphosphonate - Organophosphonic acid - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms.
• External Descriptors: 1,1-bis(phosphonic acid)

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CA2 Tclin Carbonic anhydrase II (17698 Activities)

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THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

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CA1 Tclin Carbonic anhydrase I (13240 Activities)

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CA5A Tclin Carbonic anhydrase VA (1168 Activities)

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OTC Tchem Ornithine carbamoyltransferase (24 Activities)

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CA9 Tclin Carbonic anhydrase IX (8255 Activities)

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A549 (127892 Activities)

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HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

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Hydroxyapatite (165 Activities)

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Associated Targets(non-human)

CA4 Carbonic anhydrase IV (1713 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Mmp2 Matrix metalloproteinase-2 (12 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Escherichia coli (133304 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

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Fe(3+)-Zn(2+) purple acid phosphatase (65 Activities)

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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

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traI Type IV secretion-like conjugative transfer relaxase protein TraI (23 Activities)

Discover Target: traI

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water.
• Sensitivity: Heat & Light sensitive
• Melt Point(°C): 204 °C
• Molecular Weight: 176.000 g/mol
• XLogP3: -3.300
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 175.964 Da
• Monoisotopic Mass: 175.964 Da
• Topological Polar Surface Area: 115.000 Ų
• Heavy Atom Count: 9
• Formal Charge: 0
• Complexity: 151.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Jiangbin Han, Lijuan Zhai, Jie Wang, Biying Dai, Huiyue Lu, Jiao Chen, Xiaoli Wang, Yuyu Wu, Wen Qian.  (2025)  Mechanism-based perspective on metal ion-induced signal instability and development of a robust LC-MS/MS method for trace quantification of hetrombopag in plasma.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:40639095] [10.1016/j.jpba.2025.117049]