MK 212 hydrochloride - ≥99% , CAS No.61655-58-1

CAS: 61655-58-1 Cat. No.: M276020 Molecular Weight: 235.11 EC Number: 262-883-0 PubChem CID: 198421

GRADE & PURITY ≥99%

Synonyms

MK-212 HCl | T0294 | Q27269784 | PFIZGLUIYAZQFU-UHFFFAOYSA-N | DTXSID60210668 | PYRAZINE, 2-CHLORO-6-(1-PIPERAZINYL)-, HYDROCHLORIDE (1:1) | FT-0759415 | 2-Chloro-6-(1-piperazinyl)pyrazine monohydrochloride | MK-212 (monohydrochloride) | MK212HCl | MK-212

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Product description：

MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex.

Specifications

Synonyms

MK-212 HCl | T0294 | Q27269784 | PFIZGLUIYAZQFU-UHFFFAOYSA-N | DTXSID60210668 | PYRAZINE, 2-CHLORO-6-(1-PIPERAZINYL)-, HYDROCHLORIDE (1:1) | FT-0759415 | 2-Chloro-6-(1-piperazinyl)pyrazine monohydrochloride | MK-212 (monohydrochloride) | MK212HCl | MK-212

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Potent, selective 5-HT 2C receptor agonist (IC 50 values are 28 and 420 nM for 5-HT 2C and 5-HT 2A receptors, respectively). Shows anxiogenic effects and decreases locomotor activity in vivo.

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 488188590
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488188590
• Canonical Smiles: C1CN(CCN1)C2=CN=CC(=N2)Cl.Cl
• IUPAC Name: 2-chloro-6-piperazin-1-ylpyrazine;hydrochloride
• InChIKey: PFIZGLUIYAZQFU-UHFFFAOYSA-N
• INCHI: 1S/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H
• Isomeric SMILES: C1CN(CCN1)C2=CN=CC(=N2)Cl.Cl
• WGK Germany: 3
• PubChem CID: 198421
• Molecular Weight: 235.11

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Diazinanes
      • Subclass Piperazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Diazinanes
• Subclass: Piperazines
• Intermediate Tree Nodes: Not available
• Direct Parent: N-arylpiperazines
• Alternative Parents: Dialkylarylamines Aminopyrazines Imidolactams Aryl chlorides Heteroaromatic compounds Dialkylamines Azacyclic compounds Organopnictogen compounds Organochlorides Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: N-arylpiperazine - Dialkylarylamine - Aminopyrazine - Aryl chloride - Aryl halide - Pyrazine - Imidolactam - Heteroaromatic compound - Secondary aliphatic amine - Azacycle - Secondary amine - Organonitrogen compound - Organochloride - Organohalogen compound - Amine - Hydrocarbon derivative - Organopnictogen compound - Organic nitrogen compound - Hydrochloride - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as n-arylpiperazines. These are organic compounds containing a piperazine ring where the nitrogen ring atom carries an aryl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water to 50 mM
• Molecular Weight: 235.110 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 234.044 Da
• Monoisotopic Mass: 234.044 Da
• Topological Polar Surface Area: 41.100 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 160.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3