NAMPT inhibitor-linker 1 - Moligand™, ≥98% , CAS No.2241019-57-6

CAS: 2241019-57-6 Cat. No.: N647454 Molecular Weight: 668.71 PubChem CID: 137628672

GRADE & PURITY Moligand™, ≥98%

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC , composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC 50 s of <3 pM and 9 pM, respectively.

In Vitro

ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC 50 s of <3 pM and 9 pM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female scid-beige (SCID bg) mice Dosage: 20 mg/kg Administration: A single intravenous injection (i.v.) for 28 days Result: Significantly inhibited the growth of tumor in mice.

Form:Solid

IC50& Target:Traditional Cytotoxic Agents

Specifications

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC , composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit express

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C1CN(CCN1C2=CC=C(C=C2)C(=O)NCC3=C(C=C(C=C3)NC(=O)C4CC4C5=CN=CC=C5)F)C(=O)CCOCCN6C(=O)C=CC6=O
• IUPAC Name: 4-[4-[3-[2-(2,5-dioxopyrrol-1-yl)ethoxy]propanoyl]piperazin-1-yl]-N-[[2-fluoro-4-[[(1S,2S)-2-pyridin-3-ylcyclopropanecarbonyl]amino]phenyl]methyl]benzamide
• InChIKey: ZIJGVXBDFVHKQP-IHLOFXLRSA-N
• INCHI: 1S/C36H37FN6O6/c37-31-20-27(40-36(48)30-21-29(30)25-2-1-12-38-22-25)6-3-26(31)23-39-35(47)24-4-7-28(8-5-24)41-13-15-42(16-14-41)32(44)11-18-49-19-17-43-33(45)9-10-34(43)46/h1-10,12,20,22,29-30H,11,13-19,21,23H2,(H,39,47)(H,40,48)/t29-,30+/m1/s1
• PubChem CID: 137628672
• Molecular Weight: 668.71

Chemical and Physical Properties

• Solubility: DMSO : 12.5 mg/mL (18.69 mM; ultrasonic and warming and heat to 60°C)
• Sensitivity: Light sensitive；Heat sensitive