≥97%(GC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
(+)-nootkatone, a bicyclic conjugated sesquiterpene ketone with a grapefruit-like flavor, is commonly used in fragrance, food, cosmetics and pharmaceutical industry. It can be synthesized from (+)-valencene via biotransformation. (+)-nootkatone is the active ingredient responsible for the antiplatelet effect of Cyperus rotundus, a well-known oriental traditional medicine.
This compound belongs to the class of organic compounds known as eremophilane, 8,9-secoeremophilane and furoeremophilane sesquiterpenoids. These are sesquiterpenoids with a structure based either on the eremophilane skeleton, its 8,9-seco derivative, or the furoeremophilane skeleton. Eremophilanes have been shown to be derived from eudesmanes by migration of the methyl group at C-10 to C-5.
External Descriptors
sesquiterpenoid
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Chongshan Dai, Xueyong Zhang, Jiahao Lin, Jianzhong Shen. (2023) Nootkatone Supplementation Ameliorates Carbon Tetrachloride-Induced Acute Liver Injury via the Inhibition of Oxidative Stress, NF-κB Pathways, and the Activation of Nrf2/HO-1 Pathway. Antioxidants, 12 (1):(194). [PMID:36671056][10.3390/antiox12010194]
2.Ruige Yang, Meiyue Han, Jiangping Fan, Wanqing Cheng, Nannan Ma, Xiaoting Yan, Yong Guo. (2021) Development of Novel (+)-Nootkatone Thioethers Containing 1,3,4-Oxadiazole/Thiadiazole Moieties as Insecticide Candidates against Three Species of Insect Pests. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:34919380][10.1021/acs.jafc.1c05853]
3.Yong Guo, Enhua Hou, Nannan Ma, Zhiyan Liu, Jiangping Fan, Ruige Yang. (2020) Discovery, biological evaluation and docking studies of novel N-acyl-2-aminothiazoles fused (+)-nootkatone from Citrus paradisi Macf. as potential α-glucosidase inhibitors. BIOORGANIC CHEMISTRY, [PMID:32987307][10.1016/j.bioorg.2020.104294]
4.Yong Guo, Zhiyan Liu, Enhua Hou, Nannan Ma, Jiangping Fan, Cheng-Yun Jin, Ruige Yang. (2020) Non-food bioactive natural forest products as insecticide candidates: Preparation, biological evaluation and molecular docking studies of novel N-(1,3-thiazol-2- yl)carboxamides fused (+)-nootkatone from Chamaecyparis nootkatensis [D. Don] Spach. INDUSTRIAL CROPS AND PRODUCTS, [PMID:][10.1016/j.indcrop.2020.112864]
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