Norathyriol - Moligand™,≥98% , CAS No.3542-72-1

CAS: 3542-72-1 Cat. No.: N649498 Molecular Weight: 260.20 PubChem CID: 5281656

GRADE & PURITY Moligand™, ≥98%

Synonyms

AKOS028108772 | 1,3,6,7-Tetrahydroxyxanthone | AMY36806 | DTXSID30188901 | HY-N1029 | Norathyriol | NRA | BDBM50155447 | CHEBI:7622 | MS-23663 | Mangiferitin | 9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy- | Q27089365 | SCHEMBL2418732 | 1,3,6,7-Tetrahydroxyxant

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC 50 of 3.12 μM. Norathyriol inhibits PPARα , PPARβ , and PPARγ with IC 50 s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively . Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

Specifications

Synonyms

AKOS028108772 | 1, 3, 6, 7-Tetrahydroxyxanthone | AMY36806 | DTXSID30188901 | HY-N1029 | Norathyriol | NRA | BDBM50155447 | CHEBI:7622 | MS-23663 | Mangiferitin | 9H-Xanthen-9-one, 1, 3, 6, 7-tetrahydroxy- | Q27089365 | SCHEMBL2418732 | 1, 3, 6, 7-Tetrahydroxyxant

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera . Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC 50 of 3.12u2009μM. Norathyriol inhibits PPARα , PPARβ , and PPARγ with IC 50 s of 92.8 µM, 102.4 µM, and 153.5

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C1=C(C=C2C(=C1O)C(=O)C3=CC(=C(C=C3O2)O)O)O
• IUPAC Name: 1,3,6,7-tetrahydroxyxanthen-9-one
• InChIKey: ZHTQCPCDXKMMLU-UHFFFAOYSA-N
• INCHI: 1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H
• Isomeric SMILES: C1=C(C=C2C(=C1O)C(=O)C3=CC(=C(C=C3O2)O)O)O
• Alternate CAS: 3542-72-1
• PubChem CID: 5281656
• MeSH Entry Terms: norathyriol
• Molecular Weight: 260.20

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Benzopyrans
      • Subclass 1-benzopyrans
        • Level5 Dibenzopyrans
          • Level6 Xanthenes
            • Level7 Xanthones

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Benzopyrans
• Subclass: 1-benzopyrans
• Intermediate Tree Nodes: Dibenzopyrans - Xanthenes
• Direct Parent: Xanthones
• Alternative Parents: Chromones Pyranones and derivatives 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Heteroaromatic compounds Polyols Oxacyclic compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Xanthone - Chromone - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Pyranone - Pyran - Benzenoid - Heteroaromatic compound - Vinylogous acid - Polyol - Oxacycle - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as xanthones. These are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring.
• External Descriptors: xanthenes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ACE Tclin Angiotensin-converting enzyme (1423 Activities)

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MAOA Tclin Monoamine oxidase A (11911 Activities)

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XDH Tclin Xanthine dehydrogenase (1038 Activities)

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MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)

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FASN Tchem Fatty acid synthase (3390 Activities)

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MMP12 Tchem Matrix metalloproteinase 12 (1130 Activities)

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MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)

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COLO 320 (353 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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MCF7 (126967 Activities)

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HepG2 (196354 Activities)

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KB (17409 Activities)

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MDA-MB-231 (73002 Activities)

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NUDT1 Tchem 7,8-dihydro-8-oxoguanine triphosphatase (280 Activities)

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Associated Targets(non-human)

Mmp13 Matrix metalloproteinase 13 (19 Activities)

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Mmp2 Matrix metalloproteinase-2 (12 Activities)

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Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Staphylococcus aureus (210822 Activities)

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Salmonella typhi (4293 Activities)

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Shigella sonnei (625 Activities)

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Bacillus subtilis (32866 Activities)

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Enterococcus faecalis (29875 Activities)

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Rattus norvegicus (775804 Activities)

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RAW264.7 (28094 Activities)

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Man1 Alpha-mannosidase (188 Activities)

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FUCA1 Alpha-L-fucosidase 1 (358 Activities)

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (384.32 mM; Need ultrasonic) H2O : <0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
• Molecular Weight: 260.200 g/mol
• XLogP3: 2.100
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 260.032 Da
• Monoisotopic Mass: 260.032 Da
• Topological Polar Surface Area: 107.000 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 372.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1