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PD-1/PD-L1-IN-29 , CAS No.2665734-13-2
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Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
PD-1/PD-L1-IN-29 (S4-1) is a potent PD-1/PD-L1 inhibitor with an IC 50 value of 6.1 nM. PD-1/PD-L1-IN-29 binds PD-L1 and disrupts PD-1/PD-L1 interactions, induces PD-L1 dimerization and internalization, improves its localization to the endoplasmic reticulum, and promotes PD-L1 entry into the endoplasmic reticulum. PD-1/PD-L1-IN-29 has anticancer activity.
In Vitro
PD-1/PD-L1-IN-29(S4-1) (10 or 20 μM, 48 h) can increase the cytotoxicity of PBMCs against A375 tumor cells by blocking PD-1/PD-L1 interaction and restoring the activation state of PBMCs, with little direct killing effect on tumor cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PD-1/PD-L1-IN-29(S4-1)(10 or 25 mg/kg, i.p., 12 days) significantly inhibits tumour growth in the MC38 colorectal tumour mouse model, as observed in both the low and high dose groups (10 and 25 mg/kg), with inhibition rates of 65.9% and 88.8% respectively . The pharmacokinetic parameters of PD-1/PD-L1-IN-29(S4-1) in mice Parameters iv (5 mg/kg) po (50 mg/kg) T 1/2 (h) 9.78 4.77 T max (h) 0.08 0.92 C max (ng/mL) 6290 260.67 AUC 0-t (h*ng/mL) 3466.58/td> 808.04 AUC 0-∞ (h*ng/mL) 3566.62 830.34 CL (mL/h/kg) 1404.22 - MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
Specifications
Biochemical and Physiological Mechanisms
PD-1/PD-L1-IN-29 (S4-1) is a potent PD-1/PD-L1 inhibitor with an IC 50 value of 6.1 nM. PD-1/PD-L1-IN-29 binds PD-L1 and disrupts PD-1/PD-L1 interactions, induces PD-L1 dimerization and internalization, improves its localization to the endoplasmic reticul
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Names and Identifiers
| Molecular Weight | 460.48 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
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