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· · COA & SDS available for every product · Same-day shipping on in-stock items PF 06465469 - ≥98% , CAS No.1407966-77-1
Synonyms
E98988 | HY-108691 | SCHEMBL22223727 | 1407966-77-1 | AKOS024458306 | Discontinued See A191400 | Discontinued See A191400' | BDBM50399459 | 3-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(3-methyl-4-propan-2-ylphenyl)benz
Shipped In
Ice chest + Ice pads
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Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Product description
PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM.
Specifications Synonyms
E98988 | HY-108691 | SCHEMBL22223727 | 1407966-77-1 | AKOS024458306 | Discontinued See A191400 | Discontinued See A191400' | BDBM50399459 | 3-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3, 4-d]pyrimidin-3-yl]-N-(3-methyl-4-propan-2-ylphenyl)benz
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Potent inhibitor of interleukin-2 inducible T cell kinase (ITK) (IC50= 2 nM). Also exhibits inhibitory activity against Bruton's tyrosine kinase (BTK) (IC50= 2 nM). Displays nanomolar potencies in a cell-based IP1 assay and human whole blood assay (IC50va
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Canonical Smiles CC1=C(C=CC(=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)C5CCCN(C5)C(=O)C=C)C(C)C IUPAC Name 3-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(3-methyl-4-propan-2-ylphenyl)benzamide InChIKey CGJVMKJGKFEHTL-HSZRJFAPSA-N INCHI 1S/C30H33N7O2/c1-5-25(38)36-13-7-10-23(16-36)37-29-26(28(31)32-17-33-29)27(35-37)20-8-6-9-21(15-20)30(39)34-22-11-12-24(18(2)3)19(4)14-22/h5-6,8-9,11-12,14-15,17-18,23H,1,7,10,13,16H2,2-4H3,(H,34,39)(H2,31,32,33)/t23-/m1/s1 Isomeric SMILES CC1=C(C=CC(=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)[C@@H]5CCCN(C5)C(=O)C=C)C(C)C PubChem CID 71450146 Molecular Weight 523.63
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Benzenoids Class Benzene and substituted derivatives Subclass Anilides Intermediate Tree Nodes Aromatic anilides Direct Parent Benzanilides Alternative Parents Phenylpyrazoles Benzamides Pyrazolo[3,4-d]pyrimidines Phenylpropanes Cumenes N-acylpiperidines Benzoyl derivatives Toluenes Aminopyrimidines and derivatives Imidolactams Heteroaromatic compounds Tertiary carboxylic acid amides Acrylic acids and derivatives Secondary carboxylic acid amides Amino acids and derivatives Azacyclic compounds Hydrocarbon derivatives Organic oxides Carbonyl compounds Primary amines Molecular Framework Aromatic heteropolycyclic compounds Substituents Benzanilide - Phenylpyrazole - Phenylpropane - Pyrazolopyrimidine - N-acyl-piperidine - Cumene - Benzoic acid or derivatives - Benzamide - Pyrazolo[3,4-d]pyrimidine - Benzoyl - Toluene - Aminopyrimidine - Imidolactam - Piperidine - Pyrimidine - Pyrazole - Tertiary carboxylic acid amide - Azole - Heteroaromatic compound - Acrylic acid or derivatives - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Organoheterocyclic compound - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Amine - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Primary amine - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 2.62, Max Conc. mM: 5 with gentle warming Molecular Weight 523.600 g/mol XLogP3 4.400 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 6 Exact Mass 523.27 Da Monoisotopic Mass 523.27 Da Topological Polar Surface Area 119.000 Ų Heavy Atom Count 39 Formal Charge 0 Complexity 883.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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