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PFK158 - ≥95% , CAS No.1462249-75-7

CAS: 1462249-75-7 Cat. No.: P414193 Molecular Weight: 328.29 PubChem CID: 71730058
COA
PFK158 - ≥95% CAS No(1462249-75-7) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY ≥95%
Synonyms
2HOK1JQ203 | HY-12203 | N17011 | (E)-1-(pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one | AC-35725 | s8807 | 2-Propen-1-one, 1-(4-pyridinyl)-3-(7-(trifluoromethyl)-2-quinolinyl)-, (2E)- | SCHEMBL15287558 | UNII-2HOK1JQ203 | (E)-1-pyridin
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5mg
P414193-5mg
3

$183.90

$237.90
Save $54.00 (22.70%)
10mg
P414193-10mg
2

$264.90

$343.90
Save $79.00 (22.97%)
25mg
P414193-25mg
2
$631.90
50mg
P414193-50mg
2

$938.90

$1,133.90
Save $195.00 (17.20%)
100mg
P414193-100mg
2

$1,306.90

$1,693.90
Save $387.00 (22.85%)
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews
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Why this grade

≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

PFK158 PFK158 is a potent and selective inhibitor of PFKFB3 . It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.


Targets

PFKFB3


In vitro

PFK158 results in reduced glucose uptake, ATP production, lactate release as well as induction of apoptosis in gynecologic cancer cells. PFK158 treatment sensitizes chemoresistant cells and induces cell death.

Specifications

Synonyms
2HOK1JQ203 | HY-12203 | N17011 | (E)-1-(pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one | AC-35725 | s8807 | 2-Propen-1-one, 1-(4-pyridinyl)-3-(7-(trifluoromethyl)-2-quinolinyl)-, (2E)- | SCHEMBL15287558 | UNII-2HOK1JQ203 | (E)-1-pyridin
Specifications & Purity
≥95%
Biochemical and Physiological Mechanisms
PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥95%
Product Properties
ALogP4.108
Rotatable Bond4
Names and Identifiers
Pubchem Sid504772213
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504772213
Canonical SmilesC1=CC(=CC2=C1C=CC(=N2)C=CC(=O)C3=CC=NC=C3)C(F)(F)F
IUPAC Name(E)-1-pyridin-4-yl-3-[7-(trifluoromethyl)quinolin-2-yl]prop-2-en-1-one
InChIKeyIAJOMYABKVAZCN-AATRIKPKSA-N
INCHI1S/C18H11F3N2O/c19-18(20,21)14-3-1-12-2-4-15(23-16(12)11-14)5-6-17(24)13-7-9-22-10-8-13/h1-11H/b6-5+
Isomeric SMILES C1=CC(=CC2=C1C=CC(=N2)/C=C/C(=O)C3=CC=NC=C3)C(F)(F)F
PubChem CID 71730058
Molecular Weight 328.29

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassQuinolines and derivatives
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentQuinolines and derivatives
Alternative Parents Aryl ketones  Pyridines and derivatives  Benzenoids  Heteroaromatic compounds  Enones  Acryloyl compounds  Azacyclic compounds  Organonitrogen compounds  Organofluorides  Organic oxides  Hydrocarbon derivatives  Alkyl fluorides  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Quinoline - Aryl ketone - Pyridine - Benzenoid - Acryloyl-group - Enone - Heteroaromatic compound - Alpha,beta-unsaturated ketone - Ketone - Azacycle - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Organic nitrogen compound - Organic oxygen compound - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline moiety, which consists of a benzene ring fused to a pyrimidine ring to form benzo[b]azabenzene.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PFKFB3 Tchem 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (1469 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterobacter cloacae (7976 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
C23031126Certificate of AnalysisDec 12, 2025 P414193
C23031136Certificate of AnalysisDec 12, 2025 P414193
C23031139Certificate of AnalysisDec 12, 2025 P414193
C23031180Certificate of AnalysisDec 12, 2025 P414193
C23031187Certificate of AnalysisDec 12, 2025 P414193
Chemical and Physical Properties
SolubilitySolubility (25°C) In vitro DMSO: 14 mg/mL (42.64 mM); Ethanol: 4 mg/mL (12.18 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility14
DMSO(mM) Max Solubility42.6452222120686
Water(mg / mL) Max Solubility＜1
Molecular Weight328.300 g/mol
XLogP33.800
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass328.082 Da
Monoisotopic Mass328.082 Da
Topological Polar Surface Area42.900 Ų
Heavy Atom Count24
Formal Charge0
Complexity471.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds1
Covalently-Bonded Unit Count1
Solution Calculators
Reviews

Customer Reviews

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