Proglumide sodium salt - ≥98%(HPLC) , CAS No.99247-33-3

CAS: 99247-33-3 Cat. No.: P287748 Molecular Weight: 356.39 PubChem CID: 23677833

GRADE & PURITY ≥98%(HPLC)

Synonyms

AKOS024456624 | Proglumide sodium | FT-0727740 | HMS2234D22 | sodium;4-benzamido-5-(dipropylamino)-5-oxopentanoate | sodium 4-benzamido-5-(dipropylamino)-5-oxopentanoate | Proglumide (sodium) | 4-BENZOYLAMINO-5-DIPROPYLAMINO-5-OXOPENTANOIC ACID SODIUM SAL

Storage

Store at 2-8°C,Argon charged,Desiccated

Shipped In

Wet ice

Overview

Application：

Proglumide sodium salt has been used to study the effects of proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L.

Specifications

Synonyms

AKOS024456624 | Proglumide sodium | FT-0727740 | HMS2234D22 | sodium;4-benzamido-5-(dipropylamino)-5-oxopentanoate | sodium 4-benzamido-5-(dipropylamino)-5-oxopentanoate | Proglumide (sodium) | 4-BENZOYLAMINO-5-DIPROPYLAMINO-5-OXOPENTANOIC ACID SODIUM SAL

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally act

Storage

Store at 2-8°C, Argon charged, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 504769620
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504769620
• Canonical Smiles: CCCN(CCC)C(=O)C(CCC(=O)[O-])NC(=O)C1=CC=CC=C1.[Na+]
• IUPAC Name: sodium;4-benzamido-5-(dipropylamino)-5-oxopentanoate
• InChIKey: UFMWGCINVOIJSO-UHFFFAOYSA-M
• INCHI: 1S/C18H26N2O4.Na/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14;/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22);/q;+1/p-1
• Isomeric SMILES: CCCN(CCC)C(=O)C(CCC(=O)[O-])NC(=O)C1=CC=CC=C1.[Na+]
• Alternate CAS: 6620-60-6
• PubChem CID: 23677833
• Molecular Weight: 356.39

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Glutamic acid and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Glutamic acid and derivatives
• Alternative Parents: Hippuric acids and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Benzoyl derivatives N-acyl amines Tertiary carboxylic acid amides Secondary carboxylic acid amides Carboxylic acid salts Carboxylic acids Monocarboxylic acids and derivatives Organic oxides Organonitrogen compounds Organic sodium salts Carbonyl compounds Hydrocarbon derivatives Organic zwitterions
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Glutamic acid or derivatives - N-acyl-alpha amino acid or derivatives - Hippuric acid or derivatives - Alpha-amino acid amide - Benzamide - Benzoic acid or derivatives - Benzoyl - N-acyl-amine - Monocyclic benzene moiety - Benzenoid - Tertiary carboxylic acid amide - Secondary carboxylic acid amide - Carboxylic acid salt - Carboxamide group - Carboxylic acid - Organic alkali metal salt - Monocarboxylic acid or derivatives - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organic zwitterion - Organic salt - Carbonyl group - Organic sodium salt - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as glutamic acid and derivatives. These are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solvent:water, Max Conc. mg/mL: 35.64, Max Conc. mM: 100
• Molecular Weight: 356.400 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 10
• Exact Mass: 356.171 Da
• Monoisotopic Mass: 356.171 Da
• Topological Polar Surface Area: 89.500 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 419.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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