Pumosetrag Hydrochloride - 10mM in DMSO , Serotonin 3 (5-HT3) receptor partial agonist, CAS No.194093-42-0, Serotonin 3 (5-HT3) receptor partial agonist

CAS: 194093-42-0 Cat. No.: P655825 Molecular Weight: 339.84

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

In Vivo

Pumosetrag displays both regional and species specificities. Pumosetrag has a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it has similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Pumosetrag shows little to no response in the regions of the mouse intestine. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors . Pumosetrag delays liquid gastric emptying in association with relaxation of the proximal stomach, stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:5-HT 3 Receptor

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

PARTIAL AGONIST

Mechanism of action

Serotonin 3 (5-HT3) receptor partial agonist

Names and Identifiers

• Isomeric SMILES: C1CN2CCC1[C@H](C2)NC(=O)C3=CNC4=C(C3=O)SC=C4.Cl
• WGK Germany: 3
• Molecular Weight: 339.84
• Reaxy-Rn: 14242456
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14242456&ln=

Associated Targets(Human)

HTR3A Tclin 5-hydroxytryptamine receptor 3A (2 Activities)

Discover Target: HTR3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)