Pyocyanin - Moligand™, ≥98% , CAS No.85-66-5

CAS: 85-66-5 Cat. No.: P275084 Molecular Weight: 210.23 EC Number: 687-347-7 PubChem CID: 6817

GRADE & PURITY Moligand™, ≥98%

Synonyms

5-methylphenazin-1-one | 5-methylphenazin-1(5H)-one | 5-methyl-1,5-dihydrophenazin-1-one | Pyocyanin | PYOCYANINE | Pyrocyanine | 5-methylphenazin-5-ium-1-olate | Pyocyanin; Pyrocyanine; Sanasin; Sanazin | Sanasin

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

5-methylphenazin-1-one | 5-methylphenazin-1(5H)-one | 5-methyl-1, 5-dihydrophenazin-1-one | Pyocyanin | PYOCYANINE | Pyrocyanine | 5-methylphenazin-5-ium-1-olate | Pyocyanin; Pyrocyanine; Sanasin; Sanazin | Sanasin

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Catalase inhibitor. Aryl hydrocarbon receptor activator (K i = 5.4 µM). Reduces gene expression of catalase. Promotes extracellular DNA release. Generates ROS. Induces apoptosis in neutrophils in vivo.

Storage

Protected from light, Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CN1C2=CC=CC=C2N=C3C1=CC=CC3=O
• IUPAC Name: 5-methylphenazin-1-one
• InChIKey: YNCMLFHHXWETLD-UHFFFAOYSA-N
• INCHI: 1S/C13H10N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8H,1H3
• Isomeric SMILES: CN1C2=CC=CC=C2N=C3C1=CC=CC3=O
• WGK Germany: 1
• PubChem CID: 6817
• Molecular Weight: 210.23

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Diazanaphthalenes
      • Subclass Benzodiazines
        • Level5 Quinoxalines
          • Level6 Phenazines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Quinoxalines
• Direct Parent: Phenazines and derivatives
• Alternative Parents: Pyrazines Benzenoids Vinylogous amides Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenazine - Benzenoid - Pyrazine - Heteroaromatic compound - Vinylogous amide - Azacycle - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenazines and derivatives. These are polycyclic aromatic compounds containing a phenazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a pyrazine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

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ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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DRD2 Tclin Dopamine D2 receptor (23596 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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DRD4 Tchem Dopamine D4 receptor (7907 Activities)

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

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HRH2 Tclin Histamine H2 receptor (5428 Activities)

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ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)

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HTR1D Tclin Serotonin 1d (5-HT1d) receptor (2897 Activities)

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HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)

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HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

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HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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HRH1 Tclin Histamine H1 receptor (7573 Activities)

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ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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OPRD1 Tclin Delta opioid receptor (15096 Activities)

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OPRK1 Tclin Kappa opioid receptor (16155 Activities)

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HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A3 Tclin Dopamine transporter (10535 Activities)

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CHRM4 Tclin Muscarinic acetylcholine receptor M4 (6041 Activities)

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CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 Activities)

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CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)

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DRD5 Tchem Dopamine D5 receptor (1597 Activities)

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ADRB3 Tclin Beta-3 adrenergic receptor (5850 Activities)

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HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

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HRH3 Tclin Histamine H3 receptor (10389 Activities)

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HTR1E Tchem Serotonin 1e (5-HT1e) receptor (696 Activities)

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Associated Targets(non-human)

Sigmar1 Sigma opioid receptor (160 Activities)

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Hrh4 Histamine H4 receptor (388 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Meloidogyne incognita (862 Activities)

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NIH3T3 (5395 Activities)

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Gabrp GABA-A receptor; anion channel (5731 Activities)

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: Clear blue solution at 5mg/ml of Ethanol; Clear blue solution at 5mg/ml of DMSO
• Sensitivity: Light sensitive; Moisture sensitive
• Molecular Weight: 210.230 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 210.079 Da
• Monoisotopic Mass: 210.079 Da
• Topological Polar Surface Area: 32.700 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 420.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Jun-Ying Han, Han-Lei Zhang, Hui Guo, An-Qi Liu, Said Nawab, Na Liu, Ming Hui, Dan-Dan Zhai, Yang-Chun Yong.  (2023)  A rational designed synthetic three-species alliance system for synergetic improvement on power generation from microbial fuel cell.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.148366]

2. Tianyu Zhou, Zhiyang Zhang.  (2025)  Centrifugation-Induced Stable Colloidal Silver Nanoparticle Aggregates for Reproducible Surface-Enhanced Raman Scattering Detection.  Biosensors-Basel,  15  (5): (298).  [PMID:40422037] [10.3390/bios15050298]

3. Xizi Long, Yuanyuan Jiang, Zhaozhong Zhu, Yu Li, Nan Hu, Junzhan Hong, Hui Wang, Fei Yang.  (2025)  Complete Uranium Bioreduction in 48 Hours: Synergistic Electron Transfer in a Synthetic Microbial Consortium.  Environmental Science and Ecotechnology,      [PMID:41211415] [10.1016/j.ese.2025.100629]