≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Pyridostatin (RR82) Trifluoroacetate Salt Pyridostatin Trifluoroacetate Salt (RR82) is a G-quadruplexe stabilizer with K d of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.
Targets
G-quadruplexe (Cell-free assay) 490 nM(Kd)
In vitro
Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC. Pyridostatin decreases EBNA1 synthesis via inhibition of G-quadruplexes.
Cell Research(from reference)
Cell lines：MRC-5–SV40 cells and various cancer cell lines
Concentrations：10 μM
Incubation Time：48 h
| ALogP | 0.425 |
|---|---|
| HBD Count | 5 |
| Rotatable Bond | 14 |
| Pubchem Sid | 504772823 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504772823 |
| Canonical Smiles | C1=CC=C2C(=C1)C(=CC(=N2)NC(=O)C3=CC(=CC(=N3)C(=O)NC4=NC5=CC=CC=C5C(=C4)OCCN)OCCN)OCCN.C(=O)(C(F)(F)F)O |
| IUPAC Name | 4-(2-aminoethoxy)-2-N,6-N-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide;2,2,2-trifluoroacetic acid |
| InChIKey | SLFYRKZWSPFGQZ-UHFFFAOYSA-N |
| INCHI | 1S/C31H32N8O5.C2HF3O2/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29;3-2(4,5)1(6)7/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41);(H,6,7) |
| Isomeric SMILES | C1=CC=C2C(=C1)C(=CC(=N2)NC(=O)C3=CC(=CC(=N3)C(=O)NC4=NC5=CC=CC=C5C(=C4)OCCN)OCCN)OCCN.C(=O)(C(F)(F)F)O |
| PubChem CID | 117064504 |
| Molecular Weight | 710.7 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 B2525206 | Certificate of Analysis | Jun 13, 2022 | P413753 |
| I22081034 | Certificate of Analysis | Jun 13, 2022 | P413753 |
| I22081037 | Certificate of Analysis | Jun 13, 2022 | P413753 |
| I22081038 | Certificate of Analysis | Jun 13, 2022 | P413753 |
| I2525084 | Certificate of Analysis | Jun 13, 2022 | P413753 |
| Solubility | Solubility (25°C) In vitro DMSO: 100 mg/mL (140.7 mM); Water: 100 mg/mL (140.7 mM); Ethanol: 30 mg/mL (42.21 mM); |
|---|---|
| DMSO(mg / mL) Max Solubility | 100 |
| DMSO(mM) Max Solubility | 167.6052561 |
| Water(mg / mL) Max Solubility | 100 |
| Water(mM) Max Solubility | 167.6052561 |
| Molecular Weight | 710.700 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 16 |
| Rotatable Bond Count | 13 |
| Exact Mass | 710.242 Da |
| Monoisotopic Mass | 710.242 Da |
| Topological Polar Surface Area | 240.000 Ų |
| Heavy Atom Count | 51 |
| Formal Charge | 0 |
| Complexity | 934.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
