Ranitidine hydrochloride is a histamine H2-receptor antagonist used in the treatment of gastrointestinal lesions due to excessive gastric acid secretion.Potent, competitive and selective H 2 antagonist (pA 2 = 6.95 - 7.2). Inhibits gastric acid secretion
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group.
External Descriptors
hydrochloride
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Soluble in water (1.8 mg/mL), 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (7.0 mg/mL), acetic acid, methanol, ethanol (<1 mg/mL), and DMSO (≥70 mg/mL). Insoluble in chloroform.
Sensitivity
Air & heat sensitive
Melt Point(°C)
135 °C(dec.)
Molecular Weight
350.870 g/mol
XLogP3
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Rotatable Bond Count
9
Exact Mass
350.118 Da
Monoisotopic Mass
350.118 Da
Topological Polar Surface Area
112.000 Ų
Heavy Atom Count
22
Formal Charge
0
Complexity
347.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
1
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
1
Covalently-Bonded Unit Count
2
References
1.Zhizhuo Chai, Jingquan Wang, Yixue Dai, Erdeng Du, Hongguang Guo. (2023) Synergy between UV light and trichloroisocyanuric acid on methylisothiazolinone degradation: Performance, kinetics and degradation pathway.. ENVIRONMENTAL RESEARCH, [PMID:37481058][10.1016/j.envres.2023.116693]
2.Tao Long, Weiwei Tan, Xiangmin Tian, Zongjian Tang, Keming Hu, Liming Ge, Changdao Mu, Xinying Li, Yongbin Xu, Lei Zhao, Defu Li. (2022) Gelatin/alginate-based microspheres with sphere-in-capsule structure for spatiotemporal manipulative drug release in gastrointestinal tract. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:36521695][10.1016/j.ijbiomac.2022.12.040]
3.Yangke Long, Jian Dai, Shiyin Zhao, Yiping Su, Zhongying Wang, Zuotai Zhang. (2021) Atomically Dispersed Cobalt Sites on Graphene as Efficient Periodate Activators for Selective Organic Pollutant Degradation. ENVIRONMENTAL SCIENCE & TECHNOLOGY, [PMID:33729757][10.1021/acs.est.0c07794]
4.Fengyi Du, Yunchao Wu, Fengting Du, Lirong Zhang, Weiwei Feng, Lulu Zhao, Rong Cai, Lixia Xu, Gaorui Bian, Jiangang Li, Shengqiang Zou, Aihua Gong, Miaomiao Zhang. (2019) Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery. International Journal of Nanomedicine, [PMID:31447554][10.2147/IJN.S204237]
5.Yaqiong Guo, Yingying Xie, Jianhua Qin. (2024) A generic pump-free organ-on-a-chip platform for assessment of intestinal drug absorption. Biotechnology Journal, 19 (2):(2300390). [PMID:38375564][10.1002/biot.202300390]
6.Zhang Mei, Zhao Jingwen, Long Yingying, Li Changsong, Yang Xiaoming. (2024) Carbon Dots Employed for the Detection of Ranitidine and Elaborating the Detecting Mechanism. JOURNAL OF FLUORESCENCE, [PMID:39269550][10.1007/s10895-024-03912-5]
7.Yichong Wang, Danyan Li, Luqing Zhao, Jixiang Liu, Dan Dou, Nian Liu, Yudi Zhuo, Shengsheng Zhang. (2025) Mechanism of Yinxu Weitong Capsule in the treatment of precancerous lesions of gastric cancer based on network pharmacology and experimental validation. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:39761837][10.1016/j.jep.2024.119303]
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