Resolvin D1 - Moligand™, ≥95%, A solution in ethanol , Agonist of FPR2/ALX;Agonist of GPR32;Gating inhibitor of TRPA1, CAS No.872993-05-0, Agonist of FPR2/ALX;Agonist of GPR32;Gating inhibitor of TRPA1

CAS: 872993-05-0 Cat. No.: R341442 Molecular Weight: 376.5 PubChem CID: 53394122

GRADE & PURITY Moligand™, ≥95%, A solution in ethanol

Synonyms

17(R)-Resolvin D1 | SB48260 | RvD1 | Resolvin D1 | 7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID | 17(R)-RvD1 | DTXSID60694000

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Resolvin D1 is from a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA)(1), it is an anti-inflammatory and promotes the resolution of the inflammatory response back to a non-inflamed state.2 RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. It reduces human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM. It exhibits a dose-dependent reduction in leukocyte infiltration in a murine model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.

Resolvin D1 (RvD1) is supplied as a solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. It is recommended that this product be stored and handled in an ethanol solution. Resolvins can isomerize and degrade when put into freeze thaw conditions and/or in solvents such as dimethyl formamide or DMSO.

Specifications

Synonyms

17(R)-Resolvin D1 | SB48260 | RvD1 | Resolvin D1 | 7, 8, 17-TRIHYDROXYDOCOSA-4, 9, 11, 13, 15, 19-HEXAENOIC ACID | 17(R)-RvD1 | DTXSID60694000

Specifications & Purity

Moligand™, ≥95%, A solution in ethanol

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST, GATING INHIBITOR

Mechanism of action

Agonist of FPR2/ALX;Agonist of GPR32;Gating inhibitor of TRPA1

Purity

≥95%

Names and Identifiers

• Canonical Smiles: CCC=CCC(C=CC=CC=CC=CC(C(CC=CCCC(=O)O)O)O)O
• IUPAC Name: 7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid
• InChIKey: OIWTWACQMDFHJG-UHFFFAOYSA-N
• INCHI: 1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)
• Isomeric SMILES: CCC=CCC(C=CC=CC=CC=CC(C(CC=CCCC(=O)O)O)O)O
• PubChem CID: 53394122
• Molecular Weight: 376.5

Associated Targets(Human)

GPR32 Tchem Probable G-protein coupled receptor 32 (1 Activities)

Discover Target: GPR32

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR2 Tchem N-formyl peptide receptor 2 (1 Activities)

Discover Target: FPR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Soluble in water (0.05 mg/mL) at 25° C, PBS pH 7.2 (~0.05 mg/mL), DMSO (~50 mg/mL), DMF (~50 mg/mL), and ethanol.
• Sensitivity: Light sensitive
• Boil Point(°C): 78° C

References

1. Ding Peng-Fei, Zhang Jia-Tong, Zhu Xiao-Long, Cui Yue, Chen Chun-Lei, Liu Xun-Zhi, Shen Jun-Da, Zou Le-Xuan, Lu Yue, Zhuang Zong, Hang Chun-Hua, Li Wei.  (2025)  P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage.  Journal of Neuroinflammation,  22  (1): (1-16).  [PMID:40877894] [10.1186/s12974-025-03530-3]