≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
RO 4938581 is a potent and selective GABA A α5 inverse agonist, with a K i of 4.6 nM for GABA A α5β3γ2a , and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a ( K i , 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.
In Vitro
RO 4938581 is a potent and selective GABA A α5 inverse agonist, with a K i of 4.6 nM for GABA A α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (K i , 174, 185, 80 nM, respectively). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
RO 4938581 (0.3-1 mg/kg, p.o.) reverses a working memory impairment induced by scopolamine the delayed match to position (DMTP) task and a spatial learning impairment induced by diazepam (RO 4938581; 1-10 mg/kg, po) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Ki: 4.6 nM (GABA A α5β3γ2a), 174 nM (GABA A α1β3γ2a), 185 nM (GABA A α2β3γ2a), 80 nM (GABA A α3β3γ2a)
| Isomeric SMILES | C1C2=C(N=CN2C3=C(C=C(C=C3)Br)C4=NC=NN41)C(F)F |
|---|---|
| PubChem CID | 11624499 |
| Molecular Weight | 352.14 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Solubility | DMSO : 100 mg/mL (283.98 mM; Need ultrasonic) |
|---|---|
| Molecular Weight | 352.140 g/mol |
| XLogP3 | 2.500 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 1 |
| Exact Mass | 350.993 Da |
| Monoisotopic Mass | 350.993 Da |
| Topological Polar Surface Area | 48.500 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 401.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
