Salicin - Moligand™, 10mM in DMSO , Agonist of TAS2R16, CAS No.138-52-3, Agonist of TAS2R16

CAS: 138-52-3 Cat. No.: S408989 Molecular Weight: 286.28 Beilstein Registry Number: 89593 EC Number: 205-331-6 PubChem CID: 439503

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Salicoside,Salicine | β-D-Glucopyranoside, 2-(hydroxymethyl)phenyl

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Salicin (Salicoside, Salicine) is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects. It is a natural, non-selectiveCOX-1andCOX-2inhibitor.
In vitro

Salicin (Salicoside, Salicine) is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects. Salicin is a prodrug which is gradually transported to the lower part of the intestine, hydrolyzed to saligenin by intestinal bacteria, and converted to salicylic acid after absorption. It thus produces an antipyretic action without causing gastric injury.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

Salicoside, Salicine | β-D-Glucopyranoside, 2-(hydroxymethyl)phenyl

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Salicin (Salicoside, Salicine) is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects. It is a natural, non-selective COX-1 and COX-2 inhibitor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of TAS2R16

Names and Identifiers

• Isomeric SMILES: C1=CC=C(C(=C1)CO)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O
• WGK Germany: 3
• RTECS: LZ5901700
• Alternate CAS: 138-52-3
• PubChem CID: 439503
• NSC Number: 758201
• MeSH Entry Terms: salicin;salicyl alcohol glucoside
• Molecular Weight: 286.28
• Beilstein: 89593
• Reaxy-Rn: 89593

Associated Targets(Human)

TAS2R16 Tchem Taste receptor type 2 member 16 (0 Activities)

Discover Target: TAS2R16

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 41 mg/mL (197.79 mM); Ethanol: 41 mg/mL (197.79 mM); Water: Insoluble
• Specific Rotation[α]: -62 ° (C=3, H2O)
• Melt Point(°C): 199-202°C

References

1. Lei Chen, Ning Li, Min-Hua Zong.  (2011)  A glucose-tolerant β-glucosidase from Prunus domestica seeds: Purification and characterization.  PROCESS BIOCHEMISTRY,      [PMID:] [10.1016/j.procbio.2011.10.023]

2. Zhenyue Wang, Faidah Arina Nur, Jingyi Ma, Jianguo Wang, Chuanwang Cao.  (2019)  Effects of poplar secondary metabolites on performance and detoxification enzyme activity of Lymantria dispar.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,      [PMID:31401083] [10.1016/j.cbpc.2019.108587]

3. Xinqi Gao, Yafang Lei, Teng Sun, Yuanze Ma, Hao Guan, Li Yan.  (2025)  Evaluation of Anti-Fungal Activities of Environmentally Friendly Wood Preservative from Thermal-Induced Lignified Twigs.  Forests,  16  (1): (119).  [PMID:] [10.3390/f16010119]

4. Shangguang Du, Hao Wan, Jun Luo, Xiaohua Duan, Zhengrong Zou.  (2024)  Metabolic profiling of Citrus maxima L. seedlings in response to cadmium stress using UPLC-QTOF-MS.  PLANT PHYSIOLOGY AND BIOCHEMISTRY,      [PMID:38996714] [10.1016/j.plaphy.2024.108920]

5. Mingzhen Zhang, Cong Liu, Yan Zhang, Zhangyaoyu Yuan, Shi Chen, Huihui Zhang, Xianju Huang, Lvyi Chen, Zhinan Mei, Yuebin Ge.  (2025)  Bioactive Components, Untargeted Metabolomics and Bioinformatics of Chaenomeles speciosa Fruit on Uric Acid-Lowering Activity Assessment.  Foods,  15  (1): (20).  [PMID:41517086] [10.3390/foods15010020]