Sardomozide dihydrochloride - ≥99% , CAS No.138794-73-7

CAS: 138794-73-7 Cat. No.: S651055 Molecular Weight: 303.19 PubChem CID: 10402702

GRADE & PURITY ≥99%

Synonyms

2-(4-Carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamide dihydrochloride | Cgp 48664A | 2-(4-Carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamidedihydrochloride | HYDRAZINECARBOXIMIDAMIDE, 2-(4-(AMINOIMINOMETHYL)-2

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase ( SAMDC ) inhibitor with an IC 50 of 5 nM.

In Vitro

Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC 50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Assay

The parent CHO cell line is chronically exposed to increasing levels of Sardomozide for at least eight passages beginning at 0.1 μM . Cell lines are serially exposed to increasing concentrations until a panel of sublines is obtained resistant to 1 (CHO/1). 3 (CHO/3), 10 (CHO/10), 30 (CHO/30), and 100 (CHO/100) μM Sardomozide for comparative studies. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 5 nM (SAMDC)

Specifications

Synonyms

2-(4-Carbamimidoyl-2, 3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamide dihydrochloride | Cgp 48664A | 2-(4-Carbamimidoyl-2, 3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamidedihydrochloride | HYDRAZINECARBOXIMIDAMIDE, 2-(4-(AMINOIMINOMETHYL)-2

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase ( SAMDC ) inhibitor with an IC 50 of 5 nM.

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: C1CC(=NN=C(N)N)C2=C1C(=CC=C2)C(=N)N.Cl.Cl
• IUPAC Name: (1E)-1-(diaminomethylidenehydrazinylidene)-2,3-dihydroindene-4-carboximidamide;dihydrochloride
• InChIKey: UHEIPGJSFDAPIC-NENXIMLWSA-N
• INCHI: 1S/C11H14N6.2ClH/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15;;/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17);2*1H/b16-9+
• Isomeric SMILES: C1C/C(=N\N=C(N)N)/C2=C1C(=CC=C2)C(=N)N.Cl.Cl
• PubChem CID: 10402702
• Molecular Weight: 303.19

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Indanes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Indanes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Indanes
• Alternative Parents: Guanidines Carboximidamides Carboxamidines Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Indane - Guanidine - Carboximidamide - Carboxylic acid amidine - Amidine - Organic nitrogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as indanes. These are compounds containing an indane moiety, which consists of a cyclopentane fused to a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ODC1 Tclin Ornithine decarboxylase (70 Activities)

Discover Target: ODC1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AMD1 Tchem S-adenosylmethionine decarboxylase 1 (215 Activities)

Discover Target: AMD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO : 10 mg/mL (32.98 mM; ultrasonic and warming and heat to 60°C) H2O : 3.85 mg/mL (12.70 mM; ultrasonic and warming and heat to 60°C)
• Molecular Weight: 303.190 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 302.081 Da
• Monoisotopic Mass: 302.081 Da
• Topological Polar Surface Area: 127.000 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 368.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 3

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