10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Sodium Phenylbutyrate Sodium phenylbutyrate is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.
In vitro
Phenylbutyrate is a well-known HDAC inhibitor, which increases gene transcription of a number of genes, and also exerts neuroprotective effects. Phenylbutyrate significantly attenuates MPTP-induced depletion of striatal dopamine and loss of tyrosine hydroxylase-positive neurons in the substantia nigra. Phenylbutyrate attenuates the expression of the apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker caveolin-1, and the pro-angiogenic vascular endothelial growth factor in prostate cancer cells. Phenylbutyrate is found to act in synergy with ionizing radiation to induce apoptosis in prostate cancer cells.
In vivo
Phenylbutyrate significantly extends survival and improved both the clinical and neuropathological phenotypes in G93A transgenic ALS mice. Phenylbutyrate administration ameliorates histone hypoacetylation observed in G93A mice and induced expression of nuclear factor-kappaB (NF-kappaB) p50, the phosphorylated inhibitory subunit of NF-kappaB (pIkappaB) and beta cell lymphoma 2 (bcl-2), but reduced cytochrome c and caspase expression. Phenylbutyrate acts to phosphorylate IkappaB, translocating NF-kappaB p50 to the nucleus, or to directly acetylate NF-kappaB p50. Phenylbutyrate increases brain histone acetylation and decreased histone methylation levels as assessed by both immunocytochemistry and Western blots in a transgenic mousemodel of Huntington\'s disease (HD). Phenylbutyrate increases mRNA for components of the ubiquitin-proteosomal pathway and down-regulated caspases implicated in apoptotic cell death, and active caspase 3 immunoreactivity in the striatum.
Cell Data
cell lines：Huh7 cells harboring HCV replicon
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | C1=CC=C(C=C1)CCCC(=O)[O-].[Na+] |
|---|---|
| PubChem CID | 5258 |
| Molecular Weight | 186.18 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro Water: 100 mg/mL (45.91 mM); DMSO: Insoluble; Ethanol: Insoluble; |
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| 1. Ting Xiao, Yuan Zhi, Fangfang Tian, Feilong Huang, Xingyan Cheng, Ai Wu, Ling Tao, Zhenghong Guo, Xiangchun Shen. (2023) Ameliorative effect of black raspberry anthocyanins on diabetes retinopathy by inhibiting axis protein tyrosine phosphatase 1B-endoplasmic reticulum stress. Journal of Functional Foods, [PMID:] [10.1016/j.jff.2023.105696] |
| 2. Jing Cong, Yuehui Zhang, Xinming Yang, Yu Wang, Hui He, Mengying Wang. (2022) Anti-polycystic ovary syndrome effect of electroacupuncture: IMD inhibits ER stress-mediated apoptosis and autophagy in granulosa cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:36244114] [10.1016/j.bbrc.2022.10.030] |
| 3. Renhui Huang, Qi Shi, Shutian Zhang, Hong Lin, Chengzhi Han, Xinyi Qian, Yijun Huang, Xiaorong Ren, Jiayuan Sun, Nana Feng, Chunmei Xia, Meng Shi. (2022) Inhibition of the cGAS-STING Pathway Attenuates Lung Ischemia/Reperfusion Injury via Regulating Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells of Rats. Journal of Inflammation Research, [PMID:36091334] [10.2147/JIR.S365970] |
| 4. Zexuan Li, Xinyue Deng, Yanna Cao, Hongbo Xu, Jiangang Wang, Lamei Yuan, Hao Deng. (2025) Different GJA8 missense variants reveal distinct pathogenic mechanisms in congenital cataract. LIFE SCIENCES, [PMID:40158616] [10.1016/j.lfs.2025.123596] |
| 5. Cao Ting, Wang Xue-lian, Rao Jiang-yan, Zhu Hui-feng, Qi Hong-yi, Tian Zhen. (2024) Periplaneta americana L. extract exerts neuroprotective effects by inhibiting endoplasmic reticulum stress via AKT-dependent pathway in experimental models of Parkinson’s disease. Chinese Medicine, 19 (1): (1-24). [PMID:39538357] [10.1186/s13020-024-01029-2] |
