Sulfamethazine sodium salt - ≥99% , CAS No.1981-58-4

CAS: 1981-58-4 Cat. No.: S137739 Molecular Weight: 300.31 EC Number: 217-840-0 PubChem CID: 13456556

GRADE & PURITY ≥99%

Synonyms

AKOS015889820 | Sulfamethazine sodium salt | AKOS025311025 | SCHEMBL2348844 | SULFADIMIDINUM NATRICUM [WHO-IP LATIN] | 4,6-DIMETHYL-2-SULFANILAMIDOPYRIMIDINE SODIUM SALT | D08539 | N(SUP 1)-(4,6-DIMETHYL-2-PYRIMIDYL)SULFANILAMIDE SODIUM SALT | PANOBINOSTA

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Synonyms

AKOS015889820 | Sulfamethazine sodium salt | AKOS025311025 | SCHEMBL2348844 | SULFADIMIDINUM NATRICUM [WHO-IP LATIN] | 4, 6-DIMETHYL-2-SULFANILAMIDOPYRIMIDINE SODIUM SALT | D08539 | N(SUP 1)-(4, 6-DIMETHYL-2-PYRIMIDYL)SULFANILAMIDE SODIUM SALT | PANOBINOSTA

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for ba

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 504767412
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504767412
• Canonical Smiles: CC1=CC(=NC(=N1)[N-]S(=O)(=O)C2=CC=C(C=C2)N)C.[Na+]
• IUPAC Name: sodium;(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide
• InChIKey: NGIVTUVVBWOTNT-UHFFFAOYSA-N
• INCHI: 1S/C12H13N4O2S.Na/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;/h3-7H,13H2,1-2H3;/q-1;+1
• Isomeric SMILES: CC1=CC(=NC(=N1)[N-]S(=O)(=O)C2=CC=C(C=C2)N)C.[Na+]
• PubChem CID: 13456556
• Molecular Weight: 300.31

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Benzenesulfonamides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Benzenesulfonamides
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzenesulfonamides
• Alternative Parents: Benzenesulfonyl compounds Aniline and substituted anilines Pyrimidines and pyrimidine derivatives Sulfonyls Organosulfonic acids and derivatives Heteroaromatic compounds Azacyclic compounds Primary amines Organic zwitterions Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Benzenesulfonamide - Benzenesulfonyl group - Aniline or substituted anilines - Pyrimidine - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Heteroaromatic compound - Sulfonyl - Azacycle - Organic alkali metal salt - Organoheterocyclic compound - Amine - Organic salt - Organic zwitterion - Organic sodium salt - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Primary amine - Organosulfur compound - Organonitrogen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

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ATM Tchem Serine-protein kinase ATM (4198 Activities)

Discover Target: ATM

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POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

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POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

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BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

Discover Target: BAZ2B

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Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

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Plasmodium falciparum (966862 Activities)

Explore this target

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water
• Sensitivity: light & Heat sensitive
• Molecular Weight: 300.310 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 300.066 Da
• Monoisotopic Mass: 300.066 Da
• Topological Polar Surface Area: 95.300 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 383.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Fuwei Sun, Haibo Liu, Ziyang Chu, Peixun Zhai, Tianhu Chen, Hanlin Wang, Xuehua Zou, Dong Chen.  (2021)  The effect of isomorphic substitution on siderite activation of hydrogen peroxide: The decomposition of H2O2 and the yield of ·OH.  CHEMICAL GEOLOGY,      [PMID:] [10.1016/j.chemgeo.2021.120555]

2. Bei-Bei Wang, Xu Zhao, Li-Jian Chen, Cheng Yang, Xiu-Ping Yan.  (2021)  Functionalized Persistent Luminescence Nanoparticle-Based Aptasensor for Autofluorescence-free Determination of Kanamycin in Food Samples.  ANALYTICAL CHEMISTRY,      [PMID:33410662] [10.1021/acs.analchem.0c04648]

3. Chao Fan, Hao Tang, Licheng Wang, Yijing Li, Xusheng Wang, Shuai Wang, Xiaojing Liang.  (2020)  The preparation of a core–shell stationary phase by the in situ polymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance.  NEW JOURNAL OF CHEMISTRY,  44  (27): (11704-11709).  [PMID:] [10.1039/D0NJ01197E]

4. Rui Yang, Xiaoming Xia, Jinhua Wang, Lusheng Zhu, Jun Wang, Zulfiqar Ahmad, Lili Yang, Shushuai Mao, Yangyang Chen.  (2020)  Dose and time-dependent response of single and combined artificial contamination of sulfamethazine and copper on soil enzymatic activities.  CHEMOSPHERE,      [PMID:32092565] [10.1016/j.chemosphere.2020.126161]

5. Yuze Xie, Mingwei Wang, Xi Chen, Shufen Wang, Dandan Han, Yehong Han, Hongyuan Yan.  (2019)  3-Aminophenol-glyoxylic acid resin for the determination of triazine herbicides in tomatoes.  ANALYTICA CHIMICA ACTA,      [PMID:30926030] [10.1016/j.aca.2019.01.062]

6. Tianwei Lv, Hongyuan Yan, Jiankun Cao, Shiru Liang.  (2015)  Hydrophilic Molecularly Imprinted Resorcinol–Formaldehyde–Melamine Resin Prepared in Water with Excellent Molecular Recognition in Aqueous Matrices.  ANALYTICAL CHEMISTRY,      [PMID:26441379] [10.1021/acs.analchem.5b03253]

7. Ninghan Tang, Chaoting Shi, Xiandeng Hou, Hui Xin, Lan Wu.  (2025)  Facile and elaborate construction of MoS2 QDs@ZIF-8 as asynchronous response fluorescence sensor for naked-eye detection of tetracycline.  TALANTA,      [PMID:40101686] [10.1016/j.talanta.2025.127932]

8. Ping Zhang, Xinru Yang, Can Wang, Fuwei Sun, Haibo Liu, Tianhu Chen, Dong Chen, Ziyang Chu, Jin Zhang, Jian Huang, Fazhi Xie.  (2025)  Efficient degradation of sulfamethazine sodium via hydrogen peroxide activation in the presence of calcite: Synergistic effect of Co(II) and Cu(II).  Journal of Water Process Engineering,      [PMID:] [10.1016/j.jwpe.2025.108332]