Syk-IN-4 - ≥98% , CAS No.S658845

CAS: S658845 Cat. No.: S658845 Molecular Weight: 419.48

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC 50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers.

Appearance:Solid

IC50& Target:IC50: 0.31 nM (SYK)

In Vitro:Syk-IN-4 is a potent inhibitor of hERG with an IC 50 of 3.0 μM. Syk-IN-4 inhibits SUDHL-4 and T cell proliferation with GI 50 s of 0.24 and 2.6 µM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for ref

In Vivo:Syk-IN-4 exhibits moderate oral bioavailability (60%) following oral administration (1mg/kg) in male Hans Wistar rats. Syk-IN-4 exhibits high plasma clearance (151 mL/min/kg) combined with large volumes of distribution (1.0 L/kg respectively) follow

Biological Activity:Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC 50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers.

Specifications

Specifications & Purity

≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC1=NN(C=C1CN(C)C)C2=NC(NC3=CC=C(N(C)N=C4C(NC)=O)C4=C3)=NC=C2
• Molecular Weight: 419.48

Chemical and Physical Properties

• Solubility: DMSO : 62.5 mg/mL (148.99 mM; Need ultrasonic)