Thalidomide-4-O-CH2-COO(t-Bu) , CAS No.1950635-36-5

CAS: 1950635-36-5 Cat. No.: T1418007 Molecular Weight: 388.4 PubChem CID: 121411060

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Thalidomide -4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide , which is the final step intermediate in the synthesis of Thalidomide -4-OH. Thalidomide -4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide -4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide -4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CC(C)(C)OC(=O)COC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O
• IUPAC Name: tert-butyl 2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetate
• InChIKey: SBNNKCCXJSOWRV-UHFFFAOYSA-N
• INCHI: 1S/C19H20N2O7/c1-19(2,3)28-14(23)9-27-12-6-4-5-10-15(12)18(26)21(17(10)25)11-7-8-13(22)20-16(11)24/h4-6,11H,7-9H2,1-3H3,(H,20,22,24)
• PubChem CID: 121411060
• Molecular Weight: 388.4