≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
VBIT-4 VBIT-4 is a voltage-dependent anion channel (VDAC) oligomerization inhibitor that decreases mitochondrial DNA (mtDNA) release, type I interferon (IFN) signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus.
Targets
VDAC ; mtDNA ; IFN
| Pubchem Sid | 504773017 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773017 |
| Canonical Smiles | C1CN(CCN1C2=CC=C(C=C2)OC(F)(F)F)C(CC(=O)NC3=CC=C(C=C3)Cl)CO |
| IUPAC Name | N-(4-chlorophenyl)-4-hydroxy-3-[4-[4-(trifluoromethoxy)phenyl]piperazin-1-yl]butanamide |
| InChIKey | QYSQXVAEFPWMEM-UHFFFAOYSA-N |
| INCHI | 1S/C21H23ClF3N3O3/c22-15-1-3-16(4-2-15)26-20(30)13-18(14-29)28-11-9-27(10-12-28)17-5-7-19(8-6-17)31-21(23,24)25/h1-8,18,29H,9-14H2,(H,26,30) |
| Isomeric SMILES | C1CN(CCN1C2=CC=C(C=C2)OC(F)(F)F)C(CC(=O)NC3=CC=C(C=C3)Cl)CO |
| PubChem CID | 126697666 |
| Molecular Weight | 457.87 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Diazinanes |
| Subclass | Piperazines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylpiperazines |
| Alternative Parents | N-arylpiperazines Anilides Phenoxy compounds Phenol ethers N-arylamides Dialkylarylamines Aniline and substituted anilines N-alkylpiperazines Chlorobenzenes N-acyl amines Trihalomethanes Trialkylamines Amino acids and derivatives Vinyl chlorides Enamines Chloroalkenes Carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organofluorides Organochlorides Organic oxides Hydrocarbon derivatives Alkyl fluorides Alcohols and polyols |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | N-arylpiperazine - Phenylpiperazine - Anilide - Phenoxy compound - Aniline or substituted anilines - Dialkylarylamine - N-arylamide - Tertiary aliphatic/aromatic amine - Phenol ether - N-alkylpiperazine - Halobenzene - Chlorobenzene - Fatty acyl - Benzenoid - N-acyl-amine - Fatty amide - Monocyclic benzene moiety - Trihalomethane - Tertiary aliphatic amine - Tertiary amine - Carboxamide group - Amino acid or derivatives - Azacycle - Chloroalkene - Haloalkene - Vinyl halide - Vinyl chloride - Enamine - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Halomethane - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Alcohol - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 I2216557 | Certificate of Analysis | Jun 09, 2025 | V413014 |
| I2216558 | Certificate of Analysis | Jun 09, 2025 | V413014 |
| I2216559 | Certificate of Analysis | Jun 09, 2025 | V413014 |
| I2216561 | Certificate of Analysis | Jun 09, 2025 | V413014 |
| I2216556 | Certificate of Analysis | Jun 20, 2022 | V413014 |
| J2310487 | Certificate of Analysis | Jun 20, 2022 | V413014 |
| K2328125 | Certificate of Analysis | Jun 20, 2022 | V413014 |
| Solubility | Solubility (25°C) In vitro DMSO: 92 mg/mL (200.93 mM); Ethanol: 92 mg/mL (200.93 mM); Water: Insoluble; |
|---|---|
| Molecular Weight | 457.900 g/mol |
| XLogP3 | 3.900 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 7 |
| Exact Mass | 457.138 Da |
| Monoisotopic Mass | 457.138 Da |
| Topological Polar Surface Area | 65.000 Ų |
| Heavy Atom Count | 31 |
| Formal Charge | 0 |
| Complexity | 560.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. You Yi-ping, Yan Liang, Ke Hua-yu, Li Ya-ping, Shi Zi-jian, Zhou Zhi-ya, Yang Hai-yan, Yuan Tao, Gan Ying-qing, Lu Na, Xu Li-hui, Hu Bo, Ou-Yang Dong-yun, Zha Qing-bing, He Xian-hui. (2024) Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages. ACTA PHARMACOLOGICA SINICA, [PMID:39223367] [10.1038/s41401-024-01376-8] |
| 2. Jinpeng Lv, Huansha Zhang, Wenhao Yu, Peiwen Jiang, Chuanwei Yin, Wenhui Xu, Yan Cao, Rongyin Gao. (2026) Targeting VDAC1-dependent mtDNA release attenuates fibroblast innate immune activation and vitiligo pathogenesis. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:41722540] [10.1016/j.intimp.2026.116411] |
| 3. Lv Jinpeng, Xu Wenhui, Jiang Peiwen, Yu Wenhao, Xue Hui, Hu Nan, Cao Yan, Zhang Huansha, Yin Chuanwei, Gao Rongyin. (2026) Mitochondrial DNA release via VDAC1 in keratinocytes: a key driver of innate immunity and vitiligo pathogenesis. Cell Death & Disease, [PMID:] [10.1038/s41419-026-08585-5] |
