1-Hydroxypyridine-2-thione zinc salt - Moligand™, ≥96% , Activator of K v7.1;Activator of K v7.2;Activator of K v7.4;Activator of K v7.5, CAS No.13463-41-7, Activator of K v7.1;Activator of K v7.2;Activator of K v7.4;Activator of K v7.5

CAS: 13463-41-7 Cat. No.: H122405 Molecular Weight: 317.7 EC Number: 236-671-3

GRADE & PURITY Moligand™, ≥96%

Synonyms

2-Mercaptopyridine N-Oxide Zinc Salt | Bis(2-pyridylthio) Zinc 1,1'-Dioxide | 2-Pyridinethiol 1-Oxide Zinc Salt | Zinc Pyrithione

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

2-Mercaptopyridine N-Oxide Zinc Salt | Bis(2-pyridylthio) Zinc 1, 1'-Dioxide | 2-Pyridinethiol 1-Oxide Zinc Salt | Zinc Pyrithione

Specifications & Purity

Moligand™, ≥96%

Biochemical and Physiological Mechanisms

Antibiotic agent. Potent K V 7 channel activator. Augments KCNQ1, -2, -4, and 5 channel currents. Fungal membrane transport inhibitor. Shows fungistatic and bacteriostatic effects in vivo.

Storage

Room temperature

Shipped In

Normal

Grade

Moligand™

Action Type

ACTIVATOR

Mechanism of action

Activator of K v7.1;Activator of K v7.2;Activator of K v7.4;Activator of K v7.5

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥96%

Names and Identifiers

• WGK Germany: 3
• RTECS: ZH0950000
• UN Number: 2811
• Packing Group: I
• Molecular Weight: 317.7

Associated Targets(Human)

KCNQ4 Tclin Potassium voltage-gated channel subfamily KQT member 4 (1 Activities)

Discover Target: KCNQ4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ5 Tclin Potassium voltage-gated channel subfamily KQT member 5 (1 Activities)

Discover Target: KCNQ5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ2 Tclin Potassium voltage-gated channel subfamily KQT member 2 (1 Activities)

Discover Target: KCNQ2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ1 Tclin Potassium voltage-gated channel subfamily KQT member 1 (1 Activities)

Discover Target: KCNQ1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility in Pyridine almost transparency

References

1. Shu Zhou, Shukai Liu, Xiao Meng, Tianqi Liu, Xiaoyong Shi, Rongguo Su.  (2024)  Indirect photodegradation of zinc pyrithione: The effect of chromophoric dissolved organic matter components and seawater factors.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2024.112421]