1-Pyrenebutyric acid N-hydroxysuccinimide ester - ≥95% , CAS No.114932-60-4

CAS: 114932-60-4 Cat. No.: N134794 Molecular Weight: 385.412 EC Number: 624-781-8

GRADE & PURITY ≥95%

Synonyms

LCZC294 | PbSe | 1-Pyrenebutyric acid N-hydroxysuccinimide ester, 95% | N-Hydroxysuccinimidyl Pyrenebutanoate | 1-Pyrenebutanoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 1-Succinimidyl-3'-pyrenebutyric acid | FT-0670131 | H11454 | SCHEMBL388103 | 1-aPyreneb

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

1-Pyrenebutyric acid N-hydroxysuccinimide ester is a fluorescent probe used for environment-sensitive bioconjugates. The structure includes a pyrene and an amine-reactive hydrophobic region. 1-Pyrenebutyric acid N-hydroxysuccinimide ester (PANHS) is an aromatic chemical, which is also known as PBSE. It is a yellow solid, that is soluble in chloroform, N,N dimethyl formamide, dimethyl sulfoxide and methanol. It is used in detecting nucleic acids, characterizing cyclodextrin based polyrotaxanes, immobilizing proteins etc.
A fluorescent probe

Specifications

Synonyms

LCZC294 | PbSe | 1-Pyrenebutyric acid N-hydroxysuccinimide ester, 95% | N-Hydroxysuccinimidyl Pyrenebutanoate | 1-Pyrenebutanoic acid, 2, 5-dioxo-1-pyrrolidinyl ester | 1-Succinimidyl-3'-pyrenebutyric acid | FT-0670131 | H11454 | SCHEMBL388103 | 1-aPyreneb

Specifications & Purity

≥95%

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 504757006
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504757006
• Canonical Smiles: C1CC(=O)N(C1=O)OC(=O)CCCC2=C3C=CC4=CC=CC5=C4C3=C(C=C5)C=C2
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 4-pyren-1-ylbutanoate
• InChIKey: YBNMDCCMCLUHBL-UHFFFAOYSA-N
• INCHI: 1S/C24H19NO4/c26-20-13-14-21(27)25(20)29-22(28)6-2-3-15-7-8-18-10-9-16-4-1-5-17-11-12-19(15)24(18)23(16)17/h1,4-5,7-12H,2-3,6,13-14H2
• Isomeric SMILES: C1CC(=O)N(C1=O)OC(=O)CCCC2=C3C=CC4=CC=CC5=C4C3=C(C=C5)C=C2
• Molecular Weight: 385.412
• Reaxy-Rn: 7446471
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7446471&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Pyrenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Pyrenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrenes
• Alternative Parents: Phenanthrenes and derivatives Naphthalenes Pyrrolidine-2-ones Dicarboximides Lactams Carboxylic acid salts Monocarboxylic acids and derivatives Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Pyrene - Phenanthrene - Naphthalene - Pyrrolidone - 2-pyrrolidone - Dicarboximide - Pyrrolidine - Carboxylic acid salt - Lactam - Azacycle - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organoheterocyclic compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Organic salt - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as pyrenes. These are compounds containing a pyrene moiety, which consists four fused benzene rings, resulting in a flat aromatic system.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Sensitivity: Heat & Light & Moisture sensitive
• Melt Point(°C): 133 °C
• Molecular Weight: 385.400 g/mol
• XLogP3: 4.600
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 385.131 Da
• Monoisotopic Mass: 385.131 Da
• Topological Polar Surface Area: 63.700 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 660.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Min Guo, Yan Chen, Xiaohui Mo, Yanping Wang, Xinru Zhang-Peng, Yongling Du, Fangdi Hu.  (2023)  Label-free flexible immunosensor based on nitrogen-doped graphene with titanium dioxide for the determination of depression marker dendritic cell nuclear protein-1.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2023.109765]

2. Dingxin Liu, Fei Cao, Zhifeng Xu, Chunhua Zhao, Zekun Liu, Jiadong Pang, Ze-Xian Liu, Mahdieh Moghiseh, Anthony Butler, Shaoxia Liang, Weijun Fan, Jiang Yang.  (2023)  Selective Organ-Targeting Hafnium Oxide Nanoparticles with Multienzyme-Mimetic Activities Attenuate Radiation-Induced Tissue Damage.  ADVANCED MATERIALS,      [PMID:37777858] [10.1002/adma.202308098]

3. Chuantao Hou, Qiaolin Lang, Aihua Liu.  (2016)  Tailoring 1,4-naphthoquinone with electron-withdrawing group: toward developing redox polymer and FAD-GDH based hydrogel bioanode for efficient electrocatalytic glucose oxidation.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2016.06.078]

4. Lian Xu, Yan Xiao, Kun Yu, Hongshuo Pan, Jiayi Xu, Yiyun Guan, Mengke Wang, Xiangyu Xu, Hao Wang.  (2025)  Machine Learning-Assisted Chemical Tongues Based on Dual-channel Inclusion Complexes for Rapid Identification of Nonsteroidal Anti-inflammatory Drugs in Food.  ACS Sensors,      [PMID:39992799] [10.1021/acssensors.4c02806]

5. Sibo Wang, Qiu Sun, Xuelin Zhang, Huiyang Xu, Weijian Yuan, Jianfeng Wu.  (2025)  Pyrene-bridged covalent immobilization of aminoferrocene on laser-induced graphene: toward high-performance sweat glucose sensors.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.116210]