4-Biphenylcarboxylic Acid - ≥99% , CAS No.92-92-2

CAS: 92-92-2 Cat. No.: B102061 Molecular Weight: 198.22 Beilstein Registry Number: 973519 EC Number: 202-203-1

GRADE & PURITY ≥99%

Synonyms

4-Carboxy-1,1'-biphenyl) | AS-2102 | NSC 23040 | 1,1'-biphenyl-4-carboxylic acid | AR3938 | NSC23040 | NSC-23040 | HMS1577C04 | BDBM50060971 | 4-Biphenylcarboxylicacid | A844391 | [1,1'-biphenyl]-4carboxylic acid | [1,1'-Biphenyl]-4-carboxylic acid | SCHE

Storage

Room temperature

Shipped In

Normal

Overview

Biphenyl-4-carboxylic acid is employed in the synthesis, characterization of europium, terbium complexes.

Specifications

Synonyms

4-Carboxy-1, 1'-biphenyl) | AS-2102 | NSC 23040 | 1, 1'-biphenyl-4-carboxylic acid | AR3938 | NSC23040 | NSC-23040 | HMS1577C04 | BDBM50060971 | 4-Biphenylcarboxylicacid | A844391 | [1, 1'-biphenyl]-4carboxylic acid | [1, 1'-Biphenyl]-4-carboxylic acid | SCHE

Specifications & Purity

≥99%

Storage

Room temperature

Shipped In

Normal

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 488183835
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488183835
• Canonical Smiles: C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O
• IUPAC Name: 4-phenylbenzoic acid
• InChIKey: NNJMFJSKMRYHSR-UHFFFAOYSA-N
• INCHI: 1S/C13H10O2/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,(H,14,15)
• Isomeric SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O
• WGK Germany: 1
• RTECS: DV1925100
• Molecular Weight: 198.22
• Beilstein: 973519
• Reaxy-Rn: 973519
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=973519&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: Benzoic acids Benzoyl derivatives Monocarboxylic acids and derivatives Carboxylic acids Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Biphenyl - Benzoic acid - Benzoic acid or derivatives - Benzoyl - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TYR Tclin Tyrosinase (717 Activities)

Discover Target: TYR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VEGFA Tclin Vascular endothelial growth factor A (159 Activities)

Discover Target: VEGFA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRG Tclin Retinoid X receptor gamma (646 Activities)

Discover Target: RXRG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 Activities)

Discover Target: RXRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRB Tclin Retinoid X receptor beta (726 Activities)

Discover Target: RXRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALB Tchem Serum albumin (2651 Activities)

Discover Target: ALB

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SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)

Discover Target: SLC16A1

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Associated Targets(non-human)

Ttr Transthyretin (14 Activities)

Discover Target: Ttr

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

E2 Human papillomavirus regulatory protein E2 (38 Activities)

Discover Target: E2

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Human papillomavirus (81 Activities)

Explore this target

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: Insoluble in water, soluble in ether, benzene, ethanol
• Melt Point(°C): 220-225°C
• Molecular Weight: 198.220 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 198.068 Da
• Monoisotopic Mass: 198.068 Da
• Topological Polar Surface Area: 37.300 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 211.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

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5. Xing Fan, Haotian Chen, Yuan Li, Qishuai Feng, Feng Tao, Chang Xu, Xiaolei Chen, Rui Gao, Yingying Wang, Xinyu Guo, Chenkai Sun, Cheng Lv, Yu Cheng.  (2025)  Actin-Targeted Magnetic Nanomotors Mechanically Modulate the Tumor Mechanical Microenvironment for Cancer Treatment.  ACS Nano,      [PMID:39915111] [10.1021/acsnano.4c17229]

6. Tianao Xie, Yukai Shan, Win Topatana, Taorui Yang, Ruijing Shen, Shijie Li, Jiadong Chen, Yiyuan Zhu, Ziyi Lu, Yeling Liu, Tianen Chen, Yujie Gao, Yuchao Sun, Xiujun Cai, Sarun Juengpanich, Mingyu Chen.  (2025)  Targeted Intracellular Copper Reservoir Enhances Liver Cancer Immunotherapy.  Small,      [PMID:40685755] [10.1002/smll.202502783]

7. Feng Tao, Chenkai Sun, Yingze Li, Yingying Wang, Peng Ning, Xiaolei Chen, Donglei Yang, Rui Gao, Yuan Li, Chang Xu, Zihan Guo, Haotian Chen, Xing Fan, Li Peng, Cheng Lv, Xinjian Fan, Chang Chen, Yu Cheng.  (2025)  Rotational-bouncing nanomotors with atomic edges for lysosomal mechanoporation.  Matter,      [PMID:] [10.1016/j.matt.2025.102491]

8. Mengwei Chen, Jiaojiao Wu, Peng Ning, Jingjing Wang, Zuan Ma, Liqun Huang, Gustavo R. Plaza, Yajing Shen, Chang Xu, Yu Han, Maciej S. Lesniak, Zhongmin Liu, Yu Cheng.  (2019)  Remote Control of Mechanical Forces via Mitochondrial-Targeted Magnetic Nanospinners for Efficient Cancer Treatment.  Small,  16  (3): (1905424).  [PMID:31867877] [10.1002/smll.201905424]

9. Zheng Liu, Jun-Jie Fang, Zhi-Yi Wang, Yun-Peng Xie, Xing Lu.  (2025)  Modulation of Optical and Electrochemical Properties of Cu(I) Alkynyl Clusters by Carboxylic Acid Ligands.  CHEMISTRY-A EUROPEAN JOURNAL,      [PMID:40128117] [10.1002/chem.202500230]

10. Lijun Dai, Wangbo Jiao, Jia Li, Zongqiang He, Qiaoyi Lu, Chengxiang Zheng, Hugang Li, Siyao Wang, Bin Yan, Yi Lv, Haiming Fan, Penggao Dai, Xiaoli Liu.  (2025)  Intracellular Magnetic Nanodelivery of H2S and Heat Synergize to Reshape the Tumor Immune Microenvironment.  Advanced Healthcare Materials,      [PMID:40545865] [10.1002/adhm.202501617]