10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research.
In Vitro
4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity. 4-O-Methyl honokiol (20 μM) increases the expression, transcription and DNA binding activities, and nuclear translocation of PPARγ in both in prostate PC-3 and LNCap cells. 4-O-Methyl honokiol (0-30 μM) inhibits LNCaP and PC-3 cancer cells growth, causes G0/G1 phase arrest and induces apoptotic cell death, and such effects can be reversed by PPARγ antagonist. 4-O-Methyl honokiol inhibits NF-κB activity and cancer cell growth, but such effects as well as its activation of PPARγ can be abolished by knock-down of p21. 4-O-methylhonokiol (0.5, 1 and 2 μM) reduces LPS-induced release of NO, PGE2, ROS, TNF-α and IL-1β in cultured astrocytes, and amyloidogenesis in cultured astrocytes and microglial BV-2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
4-O-Methyl honokiol (40 or 80 mg/kg, i.p. everyday for 4 weeks) inhibits the growth of SW620 and PC3 tumours in SW620 and PC3 xenograft model. 4-O-Methyl honokiol significantly increases the expression of p21 and PPARγ in the tumour tissues . 4-O-Methyl honokiol (0.5 or 1 mg/kg/day daily for 3 weeks) significantly ameliorates LPS-induced memory impairment, and inhibits LPS-induced iNOS and COX-2 expression in mice. 4-O-Methyl honokiol also shows inhibitory activities against the Aβ 1-42 accumulation, and activates astrocytes and microglia in LPS-injected mice brain. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:PPARγ NF-κB
| Isomeric SMILES | COC1=C(C=C(C=C1)C2=C(C=CC(=C2)CC=C)O)CC=C |
|---|---|
| Alternate CAS | 131845-16-4,68592-15-4 |
| PubChem CID | 155160 |
| NSC Number | 293101 |
| MeSH Entry Terms | 4-O-methylhonokiol |
| Molecular Weight | 280.36 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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