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DMNB (4,5-dimethoxy-2-nitrobenzaldehyde) is a cell-permeable vanillin derivative and potent inhibitor of DNA-PK (IC50 = 15 μM). DMNB is shown in experiments to increase DR4/DR5 mRNA levels and their surface expression and decrease c-FLIP mRNA levels in K56. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair.
| CAS | 20357-25-9 |
|---|---|
| Concentración | 10mM in DMSO |
| Sinónimos | HY-100705 | NSC65590 | NSC-65590 | DMNB4,5-dimethoxy-2-nitrobenzaldehyde | Q27187519 | STK361573 | SCHEMBL211200 | AE-641/30608009 | BBL104434 | 4,5-Dimethoxy-2-nitrobenzaldehyde | 4,5-dimethoxy-2-nitro-benzaldehyde | HMS3268J17 | l-3-fluorophe | Oprea1_5 |
| Especificaciones y pureza | 10mM in DMSO |
| Condiciones de almacenamiento de almacenamiento | Store at -80°C |
| Enviado en | Dry ice packs + Cold packs |
| Product Description | DMNB (4,5-dimethoxy-2-nitrobenzaldehyde) is a cell-permeable vanillin derivative and potent inhibitor of DNA-PK (IC50 = 15 μM). DMNB is shown in experiments to increase DR4/DR5 mRNA levels and their surface expression and decrease c-FLIP mRNA levels in K56. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair. |
| Pubchem Sid | 528762549 |
| Sensibilidad | Light & air sensitive |
| Número CE | 243-762-1 |
| PubChem CID | 88505 |
| Fórmula molecular | C9H9NO5 |