≥97%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
alpha-Melanocyte Stimulating Hormone amide is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.
| Pubchem Sid | 504773585 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773585 |
| Canonical Smiles | CC(C)C(C(=O)N)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C.C(=O)(C(F)(F)F)O |
| IUPAC Name | (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;2,2,2-trifluoroacetic acid |
| InChIKey | FEOXCJFWEWYJIH-VLZMNQITSA-N |
| INCHI | 1S/C77H109N21O19S.C2HF3O2/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101;3-2(4,5)1(6)7/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83);(H,6,7)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-;/m0./s1 |
| Alternate CAS | 581-05-5 |
| PubChem CID | 145710782 |
| Molecular Weight | 1778.9 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2127052 | Certificate of Analysis | Sep 08, 2025 | M118985 |
| K2127054 | Certificate of Analysis | Sep 08, 2025 | M118985 |
| I2519635 | Certificate of Analysis | Aug 14, 2025 | M118985 |
| I2519636 | Certificate of Analysis | Aug 14, 2025 | M118985 |
| I2519640 | Certificate of Analysis | Aug 14, 2025 | M118985 |
| A2404705 | Certificate of Analysis | Dec 12, 2023 | M118985 |
| A2404706 | Certificate of Analysis | Dec 12, 2023 | M118985 |
| A2404707 | Certificate of Analysis | Dec 12, 2023 | M118985 |
| A1916135 | Certificate of Analysis | Nov 14, 2022 | M118985 |
| A1916134 | Certificate of Analysis | Nov 14, 2022 | M118985 |
| D2320085 | Certificate of Analysis | Nov 11, 2021 | M118985 |
| Solubility | solubility in water ~1 mg/ml |
|---|
| 1. Gao Rongyin, Zhang Ximei, Zou Kun, Meng Duo, Lv Jinpeng. (2023) Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway. Frontiers in Pharmacology, [PMID:36814484] [10.3389/fphar.2023.1081030] |
| 2. Lv Jinpeng, Yang Ying, Jia Bingyi, Li Siqi, Zhang Ximei, Gao Rongyin. (2021) The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation. Frontiers in Pharmacology, [PMID:34887767] [10.3389/fphar.2021.783730] |
| 3. Heyi Su, Fan Yang, Keyi Lu, Jiaxian Ma, Guangming Huo, Shengjie Li, Jianmei Li. (2024) Carnosic acid ameliorates postinflammatory hyperpigmentation by inhibiting inflammatory reaction and melanin deposition. BIOMEDICINE & PHARMACOTHERAPY, [PMID:39393328] [10.1016/j.biopha.2024.117522] |
| 4. Jinpeng Lv, Kun Zou, Chuanwei Yin, Wenhui Xu, Duo Meng, Huansha Zhang, Wenhao Yu, Peiwen Jiang, Changjun Yun, Hui Xue, Nan Hu, Rongyin Gao. (2025) Daidzin suppresses melanogenesis through ERK and AKT signaling pathways mediated MITF proteasomal degradation. EXPERIMENTAL AND MOLECULAR PATHOLOGY, [PMID:40695033] [10.1016/j.yexmp.2025.104986] |
