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AMPK-IN-3 - ≥98% , CAS No.2417674-27-0
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC 50 s of 60.7, 107 and 3820 nM for AMPK (α2) , AMPK (α1) and KDR , respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer
In Vitro
AMPK-IN-3 (100 nM) shows inhibition values for AMPK(α2), FLT1, JAK1 JH2-pseudokinase and AMPK(α1) for 64%, 43%, 41% and 29%, respectively. AMPK-IN-3 (0.195313, 0.78125, 3.125, 12.5, 50 µM; 2 h) decreases the level of p-ACC in K562 cells. AMPK-IN-3 (1-100 µM; 24, 48, 72 h) shows potent inhibition of cellular AMPK activity but not affect cell viability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: K562 cells Concentration: 0.195313, 0.78125, 3.125, 12.5, 50 µM Incubation Time: 2 h Result: Decreased cellular levels of p-ACC(Ser79) in K562 cells. Cell Viability AssayCell Line: K562 cells Concentration: 1-100 µM Incubation Time: 24, 48, 72 h Result: Showed no measurable impact on cell viability in K562 cells cultured under hypoxic conditions for 72 hours.
Form:Solid
IC50& Target:AMPK (α2) 60.7 nM (IC 50 ) AMPK (α1) 107 nM (IC 50 ) KDR 3820 nM (IC 50 )
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC 50 s of 60.7, 107 and 3820 nM for AMPK (α2) , AMPK (α1) and KDR , respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%
Names and Identifiers
| Molecular Weight | 451.56 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 115 mg/mL (254.67 mM; Need ultrasonic) |
|---|
Solution Calculators
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