Anamorelin hydrochloride - ≥99% , Ghrelin receptor agonist, CAS No.861998-00-7, Ghrelin receptor agonist

CAS: 861998-00-7 Cat. No.: A650216 Molecular Weight: 583.16 PubChem CID: 16072155

GRADE & PURITY ≥99%

Synonyms

Anamorelin hydrochloride | AC-29222 | SCHEMBL4535148 | ONO-7643 hydrochloride | MFCD23098788 | Anamorelin hydrochloride [USAN] | Q27261306 | Anamorelin hydrochloride (JAN/USAN) | RC-1291 hydrochloride;ONO-7643 hydrochloride

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).

Specifications

Synonyms

Anamorelin hydrochloride | AC-29222 | SCHEMBL4535148 | ONO-7643 hydrochloride | MFCD23098788 | Anamorelin hydrochloride [USAN] | Q27261306 | Anamorelin hydrochloride (JAN/USAN) | RC-1291 hydrochloride;ONO-7643 hydrochloride

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Anamorelin (RC-1291) hydrochloride is a potent ghrelin receptor agonist with EC 50 value of 0.74 nM in the FLIPR assay.

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Mechanism of action

Ghrelin receptor agonist

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC(C)(C(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)N3CCC[C@](C3)(CC4=CC=CC=C4)C(=O)N(C)N(C)C)N.Cl
• IUPAC Name: 2-amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide;hydrochloride
• InChIKey: VFYAEUWJFGTGGO-GHTUPXNNSA-N
• INCHI: 1S/C31H42N6O3.ClH/c1-30(2,32)28(39)34-26(18-23-20-33-25-15-10-9-14-24(23)25)27(38)37-17-11-16-31(21-37,29(40)36(5)35(3)4)19-22-12-7-6-8-13-22;/h6-10,12-15,20,26,33H,11,16-19,21,32H2,1-5H3,(H,34,39);1H/t26-,31-;/m1./s1
• Isomeric SMILES: CC(C)(C(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)N3CCC[C@](C3)(CC4=CC=CC=C4)C(=O)N(C)N(C)C)N.Cl
• Alternate CAS: 249921-19-5
• PubChem CID: 16072155
• Molecular Weight: 583.16

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Dipeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Dipeptides
• Alternative Parents: N-acyl-alpha amino acids and derivatives 3-benzylpiperidines Tryptamines and derivatives Alpha amino acid amides 3-alkylindoles Piperidinecarboxamides N-acylpiperidines Substituted pyrroles Benzene and substituted derivatives Tertiary carboxylic acid amides Heteroaromatic compounds Secondary carboxylic acid amides Carboxylic acid hydrazides Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Hydrochlorides Monoalkylamines Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-dipeptide - N-acyl-alpha amino acid or derivatives - Benzylpiperidine - 3-benzylpiperidine - Alpha-amino acid amide - Triptan - Alpha-amino acid or derivatives - 3-alkylindole - Indole - Indole or derivatives - N-acyl-piperidine - 3-piperidinecarboxamide - Piperidinecarboxamide - Monocyclic benzene moiety - Piperidine - Substituted pyrrole - Benzenoid - Pyrrole - Tertiary carboxylic acid amide - Heteroaromatic compound - Amino acid or derivatives - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid hydrazide - Organoheterocyclic compound - Azacycle - Primary amine - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Organonitrogen compound - Organooxygen compound - Carbonyl group - Organic nitrogen compound - Hydrochloride - Amine - Organic oxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: DMSO : 170 mg/mL (291.52 mM; Need ultrasonic) H2O : 50 mg/mL (85.74 mM; ultrasonic and warming and heat to 60°C)
• Sensitivity: Moisture sensitive
• Molecular Weight: 583.200 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 582.309 Da
• Monoisotopic Mass: 582.309 Da
• Topological Polar Surface Area: 115.000 Ų
• Heavy Atom Count: 41
• Formal Charge: 0
• Complexity: 904.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3