Berbamine - ≥98% , CAS No.478-61-5

CAS: 478-61-5 Cat. No.: B414342 Molecular Weight: 608.72
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
Berbaman-12-ol,6',7-trimethoxy-2,2'-dimethyl- | NCI60_003398 | BERBAMINE, (+)- | 2-27-00-00891 (Beilstein Handbook Reference) | NSC-369310 | NCGC00142548-01 | CHEBI:3063 | CCG-270219 | NCGC00017375-02 | V5KM4XJ0WM | BERBAMINE | SR-05000002322 | 16h-1,24:6
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5mg
B414342-5mg
3
$35.90
25mg
B414342-25mg
2
$112.90
100mg
B414342-100mg
2
$287.90
250mg
B414342-250mg
2
$588.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 7 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Berbamine Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB . Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) .


Targets

Bcr-Abl ; NF-κB ; CaMKII

Specifications

Synonyms
Berbaman-12-ol, 6', 7-trimethoxy-2, 2'-dimethyl- | NCI60_003398 | BERBAMINE, (+)- | 2-27-00-00891 (Beilstein Handbook Reference) | NSC-369310 | NCGC00142548-01 | CHEBI:3063 | CCG-270219 | NCGC00017375-02 | V5KM4XJ0WM | BERBAMINE | SR-05000002322 | 16h-1, 24:6
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA) induces apoptosis in human myeloma
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Product Properties
ALogP6.992
hba_count5
HBD Count1
Rotatable Bond3
Names and Identifiers
Pubchem Sid504758259
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504758259
Canonical SmilesCN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC
IUPAC Name(1S,14R)-20,21,25-trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-9-ol
InChIKeyDFOCUWZXJBAUSQ-URLMMPGGSA-N
INCHI1S/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1
Isomeric SMILES CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC
Molecular Weight 608.72
Reaxy-Rn 78902
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=78902&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassLignans, neolignans and related compounds
ClassNot available
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentLignans, neolignans and related compounds
Alternative Parents Diarylethers  Tetrahydroisoquinolines  Anisoles  Aralkylamines  Alkyl aryl ethers  1-hydroxy-2-unsubstituted benzenoids  Trialkylamines  Oxacyclic compounds  Azacyclic compounds  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Oxyneolignan skeleton - Diaryl ether - Tetrahydroisoquinoline - Anisole - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Benzenoid - Tertiary amine - Tertiary aliphatic amine - Ether - Oxacycle - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Organopnictogen compound - Organooxygen compound - Amine - Organic oxygen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as lignans, neolignans and related compounds. These are plant products of low molecular weight formed primarily from oxidative coupling of two p-propylphenol moieties. They can also be described as micromolecules with two phenylpropanoid units coupled together. They can be attached in various manners, like C5-C5', C8-C8'. Most known natural lignans are oxidized at C9 and C9´ and, based upon the way in which oxygen is incorporated into the skeleton and on the cyclization patterns, a wide range of lignans of very different structural types can be formed.
External Descriptors Isoquinoline alkaloids
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE1A Tclin Phosphodiesterase 1A (251 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Tclin Butyrylcholinesterase (7174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TERT Tchem Telomerase reverse transcriptase (2428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-937 (7138 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB (17409 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
PREP Prolyl endopeptidase (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Entamoeba histolytica (2676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Chrm1 Muscarinic acetylcholine receptor (3770 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
C2612295Certificate of AnalysisMar 13, 2026 B414342
B23071172Certificate of AnalysisOct 30, 2025 B414342
B2307544Certificate of AnalysisOct 30, 2025 B414342
B2307587Certificate of AnalysisOct 30, 2025 B414342
B2307636Certificate of AnalysisOct 30, 2025 B414342
D2419041Certificate of AnalysisSep 29, 2022 B414342
F2417075Certificate of AnalysisSep 29, 2022 B414342
Chemical and Physical Properties
SolubilitySolubility (25°C) In vitro DMSO: 100 mg/mL (164.27 mM);    
DMSO(mg / mL) Max Solubility100
DMSO(mM) Max Solubility164.278252532801
Molecular Weight608.700 g/mol
XLogP36.100
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass608.289 Da
Monoisotopic Mass608.289 Da
Topological Polar Surface Area72.900 Ų
Heavy Atom Count45
Formal Charge0
Complexity963.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Pan Wu, Yaru Fang, Kezhou Chen, Mi Wu, Wenchang Zhang, Shiyu Wang, Dongwen Liu, Junqing Gao, Huaiguo Li, Jianhua Lv, Yan Zhao.  (2023)  Study of double network hydrogels based on sodium methacrylate alginate and carboxymethyl chitosan.  EUROPEAN POLYMER JOURNAL,      [PMID:] [10.1016/j.eurpolymj.2023.112137]
2. Heng Zhang, Yizheng Zhou, Hanmo Yang, Xinyi Tao, Yinping Chen, Fuqiang Dong, Yi Sun.  (2025)  In vitro interactions of berbamine hydrochloride and azoles against Aspergillus fumigatus.  Microbiology Spectrum,      [PMID:40162754] [10.1128/spectrum.03184-24]
3. Hui Wang, Mingyu Wang, Jinku Zhang, Di Wu, Zhezhe Qi, Xinbei Dong, Xing Zhang, Hongyuan Yan, Yehong Han.  (2025)  Green synthesis of a urea–melamine–hexamethylenetetramine resin for efficient extraction and determination of berberine hydrochloride in Pudilan antiphlogistic oral liquid.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:40652811] [10.1016/j.chroma.2025.466196]
4. Xinru Wang, Jie Zhang, Jinyu Shan, Dong Yang, Jie Yang, Guangming Tian, Yunzhi Dang, Jianhua Ma.  (2025)  Polypyrrole-Modified Triple-Responsive Hydrogel Dressing Based on Bacterial Cellulose and Quaternary Ammonium Chitosan and Its Synergistic Antibacterial Mechanism.  ACS Applied Materials & Interfaces,      [PMID:40890037] [10.1021/acsami.5c12061]
5. Xinru Wang, Jinyu Shan, Jie Zhang, Dong Yang, Guangming Tian, Yunzhi Dang, Jianhua Ma.  (2025)  Synergistic thermoresponsive and photothermal antimicrobial dressing based on bacterial cellulose with surface-grafted PNIPAM and PDA-coated silver nanoparticles for chronic wound treatment.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2025.138357]
6. Mengyuan Li, Jiaming Ge, Jingwen Yao, Yuanhao Zhang, Lin Ma, Zheng Li, Xiangli Han, Ming Liu, Fei Tian, Jing Zhao.  (2025)  Multifunctional nanoplatform based on polyethylene glycol-folic acid modified UiO-66 (Zr) as drug delivery platform for enhanced therapy of cancer.  Biofabrication,  17  (3): (035012).  [PMID:40378851] [10.1088/1758-5090/add9d2]
7. Xue-Na Li, Ya-Ping Lin, Xi-Xi Ma, Yue-Fei Fang, Hui Wang, Chun-Hui Cui, Chen Zhang, Jin-You Piao, Jee-Heon Jeong, Xian Wu Cheng, Lei Xing, Hu-Lin Jiang.  (2025)  Pulmonary-Targeted Nanoparticles Interrupt the Malignant Mechanical and Biochemical Signaling Crosstalk for Idiopathic Pulmonary Fibrosis Therapy.  Advanced Science,      [PMID:41246879] [10.1002/advs.202512658]
Solution Calculators
Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.