Camptothecin-20(S)-O-propionate - 10mM in DMSO , DNA topoisomerase I inhibitor, CAS No.194414-69-2, DNA topoisomerase I inhibitor

CAS: 194414-69-2 Cat. No.: C654788 Molecular Weight: 404.42 PubChem CID: 9887472

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor .

In Vivo

Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: A tumor xenograft growing in a nude mouse (size, ∼1 cm 3 ). Dosage: 100-1000 mg/kg/day. Administration: Oral gavage, for 2, 4 and 6 days, respectively. Result: Exhibited anti-tumor effect.

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

DNA topoisomerase I inhibitor

Product Properties

• ALogP: 2

Names and Identifiers

• Isomeric SMILES: CCC(=O)O[C@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)CC
• Alternate CAS: 194414-69-2
• PubChem CID: 9887472
• Molecular Weight: 404.42