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· · COA & SDS available for every product · Same-day shipping on in-stock items CCT 241533 dihydrochloride - ≥98%(HPLC) , CAS No.1962925-28-5
Synonyms
(3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride
Storage
Room temperature,Desiccated
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Why this grade ≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Room temperature,Desiccated Ships Normal Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
(3R, 4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6, 7-dimethoxy-4-quinazolinyl]amino]-α, α-dimethyl-3-pyrrolidinemethanol dihydrochloride
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
Potent Chk2 inhibitor (IC50= 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response toetoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thym
Storage
Room temperature, Desiccated
Names and Identifiers Canonical Smiles CC(C)(C1CNCC1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)C4=C(C=CC(=C4)F)O)O.Cl.Cl IUPAC Name 4-fluoro-2-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxyquinazolin-2-yl]phenol;dihydrochloride InChIKey VCFVLTMSBOZYOU-FXKISCCRSA-N INCHI 1S/C23H27FN4O4.2ClH/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29;;/h5-9,15,17,25,29-30H,10-11H2,1-4H3,(H,26,27,28);2*1H/t15-,17-;;/m1../s1 PubChem CID 137025388 Molecular Weight 515.41
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data 3D Structure Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:water, Max Conc. mg/mL: 5.15, Max Conc. mM: 10 with gentle warming; Solvent:DMSO, Max Conc. mg/mL: 51.54, Max Conc. mM: 100
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