Chondroitin 4-sulfate sodium salt - mixture of isomers, main component: chondroitin 4-sulfate , CAS No.39455-18-0

CAS: 39455-18-0 Cat. No.: C109526 EC Number: 609-686-1

GRADE & PURITY mixture of isomers, main component: chondroitin 4-sulfate

Synonyms

Chondroitin, hydrogen sulfate | DTXSID601017238 | A843439 | Chondron | Chondroitin sulfate A sodium salt - 90%, from Bovine Cartilage | Chondroitin sulfate A sodium salt - Average MW 10,000 - 30,000 | Condrosulf | ND 3482 | Chondroitin, 6-(hydrogen sulfat

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Chondroitin, a glucosaminoglycan (GAG), is a polysaccharide chain of alternating units of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA) that can be sulfated on the either or both GalNAc and GlcA units. Chondroitin and its sulfates are frequently attached to proteins to form proteoglycans.

Specifications

Synonyms

Chondroitin, hydrogen sulfate | DTXSID601017238 | A843439 | Chondron | Chondroitin sulfate A sodium salt - 90%, from Bovine Cartilage | Chondroitin sulfate A sodium salt - Average MW 10, 000 - 30, 000 | Condrosulf | ND 3482 | Chondroitin, 6-(hydrogen sulfat

Specifications & Purity

mixture of isomers, main component: chondroitin 4-sulfate

Biochemical and Physiological Mechanisms

Chondroitin sulfate, as a kind of hydrophilic molecule with large volume and negative charge, cannot be folded into a compact spherical structure due to its poor flexibility. It can form porous hydrated gel, provide mechanical support for tissues, and all

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CC(=O)NC1C(C(C(OC1O)OS(=O)(=O)O)O)OC2C(C(C(C(O2)C(=O)O)O)O)O
• IUPAC Name: (2S,3S,4S,5R,6R)-6-[(2R,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-sulfooxyoxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
• InChIKey: KXKPYJOVDUMHGS-OSRGNVMNSA-N
• INCHI: 1S/C13H21NO15S/c1-2(15)14-3-8(7(19)13(28-11(3)22)29-30(23,24)25)26-12-6(18)4(16)5(17)9(27-12)10(20)21/h3-9,11-13,16-19,22H,1H3,(H,14,15)(H,20,21)(H,23,24,25)/t3-,4+,5+,6-,7-,8-,9+,11-,12-,13-/m1/s1
• Isomeric SMILES: CC(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1O)OS(=O)(=O)O)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C(=O)O)O)O)O
• WGK Germany: 3
• Alternate CAS: 9007-28-7
• Reaxy-Rn: 29675846
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29675846&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Sugar acids and derivatives
          • Level6 Glucuronic acid derivatives
            • Level7 Glucuronides
              • Level8 O-glucuronides

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Sugar acids and derivatives - Glucuronic acid derivatives - Glucuronides
• Direct Parent: O-glucuronides
• Alternative Parents: Disaccharides O-glycosyl compounds Beta hydroxy acids and derivatives Alkyl sulfates Sulfuric acid monoesters Oxanes Pyrans Acetamides Secondary alcohols Hemiacetals Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Oxacyclic compounds Acetals Polyols Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: 1-o-glucuronide - O-glucuronide - Disaccharide - Glycosyl compound - O-glycosyl compound - Beta-hydroxy acid - Hydroxy acid - Oxane - Pyran - Sulfuric acid monoester - Sulfate-ester - Alkyl sulfate - Sulfuric acid ester - Acetamide - Organic sulfuric acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Secondary alcohol - Hemiacetal - Oxacycle - Monocarboxylic acid or derivatives - Acetal - Carboxylic acid - Organoheterocyclic compound - Carboxylic acid derivative - Polyol - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Organic nitrogen compound - Organonitrogen compound - Alcohol - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as o-glucuronides. These are glucuronides in which the aglycone is linked to the carbohydrate unit through an O-glycosidic bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: H2O: soluble 50 mg/mL, clear to hazy, colorless to faintly yellow
• Sensitivity: moisture sensitive
• Specific Rotation[α]: -20~-30
• Melt Point(°C): >150℃
• Molecular Weight: 463.370 g/mol
• XLogP3: -4.800
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 15
• Rotatable Bond Count: 6
• Exact Mass: 463.063 Da
• Monoisotopic Mass: 463.063 Da
• Topological Polar Surface Area: 267.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 739.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 10
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Guo Rongkang, Wu Chaohan, Liu Fan, Dong Tianhua, Zhang Tao.  (2023)  Biomimetic composite hydrogel promotes new bone formation in rat bone defects through regulation of miR-19b-3p/WWP1 axis by loaded extracellular vesicles.  JOURNAL OF NANOBIOTECHNOLOGY,  21  (1): (1-23).  [PMID:38037135] [10.1186/s12951-023-02201-w]

2. Jianye Kang, Xuewei Zhang, Xinyu Yang, Xuhao Yang, Shutao Wang, Wenlong Song.  (2023)  Mucosa-Inspired Electro-Responsive Lubricating Supramolecular-Covalent Hydrogel.  ADVANCED MATERIALS,  35  (46): (2307705).  [PMID:37742109] [10.1002/adma.202307705]

3. Yufan Shi, Shuang Rong, Tingxian Guo, Ruyi Zhang, Duoxia Xu, Yahong Han, Fuguo Liu, Jiaqi Su, Hongxin Xu, Shuai Chen.  (2023)  Fabrication of compact zein-chondroitin sulfate nanocomplex by anti-solvent co-precipitation: Prevent degradation and regulate release of curcumin.  FOOD CHEMISTRY,      [PMID:37562259] [10.1016/j.foodchem.2023.137110]

4. Lili Jin, Miao He, Ying Chen, Changsheng Liu, Hongyan He.  (2023)  Reverse milling–sputtering technology to develop scalable microneedle patches for analgesia.  Materials Today Communications,      [PMID:] [10.1016/j.mtcomm.2023.106611]

5. Rumin Fu, Xinxiang Zhong, Cairong Xiao, Jian Lin, Youjun Guan, Yu Tian, Zhengnan Zhou, Guoxin Tan, Huabin Hu, Lei Zhou, Chengyun Ning.  (2023)  A stretchable, biocompatible, and self-powered hydrogel multichannel wireless sensor system based on piezoelectric barium titanate nanoparticles for health monitoring.  Nano Energy,      [PMID:] [10.1016/j.nanoen.2023.108617]

6. Yue Zhuo, Yuehui Liang, Duoxia Xu, David Julian McClements, Suqing Wang, Qi Li, Yahong Han, Fuguo Liu, Shuai Chen.  (2023)  Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:37257529] [10.1016/j.ijbiomac.2023.125109]

7. Yuan Zhang, Wenjuan Chen, Wenjing Feng, Wenhong Fang, Xiao Han, Cui Cheng.  (2023)  Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation.  CARBOHYDRATE POLYMERS,      [PMID:37173033] [10.1016/j.carbpol.2023.120937]

8. Wenhao Wang, Ao Wang, Gaofu Hu, Mengyao Bian, Lili Chen, Qian Zhao, Weilian Sun, Yanmin Wu.  (2023)  Potential of an Aligned Porous Hydrogel Scaffold Combined with Periodontal Ligament Stem Cells or Gingival Mesenchymal Stem Cells to Promote Tissue Regeneration in Rat Periodontal Defects.  ACS Biomaterials Science & Engineering,      [PMID:36942823] [10.1021/acsbiomaterials.2c01440]

9. Jiaqian Zhu, Huihui Yuan, Shunqi Zhang, Xiang Hao, Minbo Lan.  (2022)  Construction of antifouling and antibacterial polyhexamethylguanidine/chondroitin sulfate coating on polyurethane surface based on polydopamine rapid deposition.  JOURNAL OF APPLIED POLYMER SCIENCE,  139  (42): (e53009).  [PMID:] [10.1002/app.53009]

10. Min Cai, Xiaojun Li, Meng Xu, Shiqi Zhou, Lei Fan, Jingyan Huang, Cairong Xiao, Yichen Lee, Bo Yang, Le Wang, Ross William Crawford, Yin Xiao, Lei Zhou, Chengyun Ning, Yan Wang.  (2022)  Injectable Tumor Microenvironment-Modulated Hydrogels with Enhanced Chemosensitivity and Osteogenesis for Tumor-Associated Bone Defects Closed-Loop Management.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2022.138086]

11. Qiang Chen, Chunjing Guo, Xiudi Zhou, Yanguo Su, Huimin Guo, Min Cao, Jing Li, Yue Zhang, Weiyi Zhao, Xin Gao, Shuqi Mi, Daquan Chen.  (2022)  N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:35513096] [10.1016/j.ijbiomac.2022.04.180]

12. Decheng Zhang, Xiudan Lang, Ni Hui, Jiasheng Wang.  (2022)  Dual-Mode electrochemical biosensors based on Chondroitin sulfate functionalized polypyrrole nanowires for ultrafast and ultratrace detection of acetamiprid pesticide.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2022.107530]

13. Zhang Hongzhen, Xu Ronghua, Yin Zuowen, Yu Jun, Liang Ning, Geng Qian.  (2021)  Drug-Loaded Chondroitin Sulfate Microspheres Generated from Microfluidic Electrospray for Wound Healing.  MACROMOLECULAR RESEARCH,  30  (1): (36-42).  [PMID:] [10.1007/s13233-022-0001-4]

14. Shanshan Xu, Chunyu Liu, Shuya Zang, Jiaxin Li, Yashi Wang, Kebai Ren, Man Li, Zhirong Zhang, Qin He.  (2021)  Multifunctional self-delivery micelles targeting the invasion-metastasis cascade for enhanced chemotherapy against melanoma and the lung metastasis.  Asian Journal of Pharmaceutical Sciences,      [PMID:35027954] [10.1016/j.ajps.2021.08.002]

15. Bao-Liang Li, Xizhe Liu, Manman Gao, Fu Zhang, Xu Chen, Zhongyuan He, Jianmin Wang, Wei Tian, Dafu Chen, Zhiyu Zhou, Shaoyu Liu.  (2021)  Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model.  Oxidative Medicine and Cellular Longevity,      [PMID:34512867] [10.1155/2021/5608133]

16. He Yang, Zhifang Ma, Xinghua Guan, Zehong Xiang, Yue Ke, Yu Xia, Zhirong Xin, Qiang Shi, Jinghua Yin.  (2021)  Facile fabrication of diatomite-based sponge with high biocompatibility and rapid hemostasis.  JOURNAL OF APPLIED POLYMER SCIENCE,  138  (46): (51360).  [PMID:] [10.1002/app.51360]

17. Shouwei Zhang, Liu Yang, Dong Ding, Pengcheng Gao, Fan Xia, Merlin L. Bruening.  (2021)  Highly Rectifying Fluidic Diodes Based on Asymmetric Layer-by-Layer Nanofilms on Nanochannel Membranes.  ANALYTICAL CHEMISTRY,      [PMID:33625211] [10.1021/acs.analchem.0c05303]

18. Lei Zhou, Lei Fan, Feng-Miao Zhang, Yuhe Jiang, Min Cai, Cong Dai, Yi-An Luo, Ling-Jie Tu, Zheng-Nan Zhou, Xiao-Jun Li, Cheng-Yun Ning, Kai Zheng, Aldo R. Boccaccini, Guo-Xin Tan.  (2020)  Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation.  Bioactive Materials,      [PMID:33073063] [10.1016/j.bioactmat.2020.09.012]

19. Aijiao Zhou, Xumeng Wu, Wangwei Chen, Lei Liao, Pengchao Xie.  (2020)  Fabrication of hydrophobic/hydrophilic bifunctional adsorbent for the removal of sulfamethoxazole and bisphenol A in Water.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2020.104161]

20. Xiqi Ma, Xiaojuan Wang, Qi Chen, Hua He, Yixin Sun, Hui Liu, Yanan Wang, Jianbo Qu, Fang Huang.  (2019)  Glycosaminoglycan / gold nanocluster hybrid nanoparticles as a new sensing platform: Metastatic potential assessment of cancer cells.  CARBOHYDRATE POLYMERS,      [PMID:31887958] [10.1016/j.carbpol.2019.115654]

21. Feng-Miao Zhang, Lei Zhou, Zheng-Nan Zhou, Cong Dai, Lei Fan, Chang-Hao Li, Cai-Rong Xiao, Cheng-Yun Ning, Yi Liu, Jian-Qiang Du, Guo-Xin Tan.  (2019)  Bioactive glass functionalized chondroitin sulfate hydrogel with proangiogenic properties.  BIOPOLYMERS,  110  (12): (e23328).  [PMID:31454076] [10.1002/bip.23328]

22. Xiaozhi Ren, Jinxiu Li, Jiayi Li, Yuqi Jiang, Lan Li, Qingqiang Yao, Qinfei Ke, He Xu.  (2019)  Aligned porous fibrous membrane with a biomimetic surface to accelerate cartilage regeneration.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2019.03.271]

23. Yingying Qi, Jiahuan He, Fu-Rong Xiu, Xuan Yu, Yifan Li, Yongwei Lu, Xiang Gao, Zhiqi Song, Baoxin Li.  (2019)  A facile chemiluminescence sensing for ultrasensitive detection of heparin using charge effect of positively-charged AuNPs.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:30909087] [10.1016/j.saa.2019.03.073]

24. Qing Liu, Xu Yan, Qi Lai, Xingguang Su.  (2018)  Bimetallic gold/silver nanoclusters-gold nanoparticles based fluorescent sensing platform via the inner filter effect for hyaluronidase activity detection.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2018.11.040]

25. Liang Si-Si, Deng Xu, Fan Yao-Yao, Li Jun, Wang Man, Zhang Zhi-Qi.  (2018)  A ratiometric fluorometric heparin assay based on the use of CdTe and polyethyleneimine-coated carbon quantum dots.  MICROCHIMICA ACTA,  185  (11): (1-7).  [PMID:30361934] [10.1007/s00604-018-3061-6]

26. Qu Fei, Li Xiaonan, Lv Xiaoxia, You Jinmao, Han Wenli.  (2018)  Highly selective metal–organic framework-based sensor for protamine through photoinduced electron transfer.  JOURNAL OF MATERIALS SCIENCE,  54  (4): (3144-3155).  [PMID:] [10.1007/s10853-018-3041-6]

27. Lin Ma, Mengyue Zhang, Aijun Yang, Qin Wang, Fei Qu, Fengli Qu, Rong-Mei Kong.  (2018)  Sensitive fluorescence detection of heparin based on self-assembly of mesoporous silica nanoparticle–gold nanoclusters with emission enhancement characteristics.  ANALYST,  143  (22): (5388-5394).  [PMID:30295305] [10.1039/C8AN01556B]

28. Huang Jianyong, Li Fenglan, Guo Rubin, Chen Yuyuan, Wang Zhenzhen, Zhao Chengfei, Zheng Yanjie, Weng Shaohuang, Lin Xinhua.  (2018)  A signal-on ratiometric fluorometric heparin assay based on the direct interaction between amino-modified carbon dots and DNA.  MICROCHIMICA ACTA,  185  (5): (1-9).  [PMID:29680977] [10.1007/s00604-018-2798-2]

29. Fei Qu, Yanqun Liu, Haili Lao, Yaping Wang, Jinmao You.  (2017)  Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles.  NEW JOURNAL OF CHEMISTRY,  41  (19): (10592-10597).  [PMID:] [10.1039/C7NJ02381B]

30. Yadong Qiao, Zhiyi Yao, Wenqi Ge, Li Zhang, Hai-Chen Wu.  (2017)  Rapid and visual detection of heparin based on the disassembly of polyelectrolyte-induced pyrene excimers.  ORGANIC & BIOMOLECULAR CHEMISTRY,  15  (12): (2569-2574).  [PMID:28266671] [10.1039/C7OB00115K]

31. Yan Liu, Yuxuan Wu, Lei Zhou, Zhengao Wang, Cong Dai, Chengyun Ning, Guoxin Tan.  (2017)  A Dual-Bonded Approach for Improving Hydrogel Implant Stability in Cartilage Defects.  Materials,  10  (2): (191).  [PMID:28772550] [10.3390/ma10020191]

32. Long Zhao, Tao Wang, Qiang Wu, Yuan Liu, Zhoujiang Chen, Xiaohong Li.  (2017)  Fluorescent Strips of Electrospun Fibers for Ratiometric Sensing of Serum Heparin and Urine Trypsin.  ACS Applied Materials & Interfaces,      [PMID:28067489] [10.1021/acsami.6b14118]

33. Dan Yan, Yu He, Yili Ge, Gongwu Song.  (2016)  Fluorescence “turn on-off” detection of heparin and heparinase I based on the near-infrared emission polyethyleneimine capped Ag2S quantum dots.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2016.09.058]

34. Liu Dandan, Li Jinyu, Pan Hao, He Fengwei, Liu Zhidong, Wu Qingyin, Bai Chunping, Yu Shihui, Yang Xinggang.  (2016)  Potential advantages of a novel chitosan-N-acetylcysteine surface modified nanostructured lipid carrier on the performance of ophthalmic delivery of curcumin.  Scientific Reports,  6  (1): (1-14).  [PMID:27350323] [10.1038/srep28796]

35. Xiaokun Wang, Ling Chen, Xiuli Fu, Lingxin Chen, Yanjun Ding.  (2013)  Highly Sensitive Surface-Enhanced Raman Scattering Sensing of Heparin Based on Antiaggregation of Functionalized Silver Nanoparticles.  ACS Applied Materials & Interfaces,      [PMID:24107222] [10.1021/am404142e]

36. Xiuli Fu, Lingxin Chen, Jinhua Li.  (2012)  Ultrasensitive colorimetric detection of heparin based on self-assembly of gold nanoparticles on graphene oxide.  ANALYST,  137  (16): (3653-3658).  [PMID:22741162] [10.1039/C2AN35552C]

37. Xiuli Fu, Lingxin Chen, Jinhua Li, Meng Lin, Huiyan You, Wenhai Wang.  (2012)  Label-free colorimetric sensor for ultrasensitive detection of heparin based on color quenching of gold nanorods by graphene oxide.  BIOSENSORS & BIOELECTRONICS,      [PMID:22387039] [10.1016/j.bios.2012.02.008]

38. Guang Liu, Zhilang Li, Zirong Lv, Qiuping Zheng, Cunji Gao, Jianniao Tian, Xing-Can Shen.  (2024)  A self-assembled Ru nanozyme with H2O2-activated oxygenation for NIR-II photoacoustic imaging-guided photothermal/photodynamic therapy.  Materials Advances,  5  (11): (4902-4912).  [PMID:] [10.1039/D4MA00103F]

39. Jiaye Li, Fengyuan Wang, Youjun Ding, Guopu Chen, Qian Tan, Yuanjin Zhao.  (2025)  Biomimetic ECM hydrogels loaded with ADSCs and polydopamine nanoparticles for chronic wound healing.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.160764]

40. Chen-Lu Xu, Chen-Yuan Zhu, Yang-Nan Li, Jian Gao, Ye-Wang Zhang.  (2024)  Heparinase III with High Activity and Stability: Heterologous Expression, Biochemical Characterization, and Application in Depolymerization of Heparin.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38307881] [10.1021/acs.jafc.3c07197]

41. Xi Yuan, Guanghao Li, Long Huang, Meng Zheng, Jin Su, Junlai Wan, Haozhe Cheng, Hao Zhu, Xulin Jiang, Jun Xiao.  (2024)  Hydroxypropyl Chitin-Oxidized chondroitin sulfate double-network hydrogel assists microfracture technique to enhance cartilage regeneration.  MATERIALS & DESIGN,      [PMID:] [10.1016/j.matdes.2024.112656]

42. Yuxia Liu, Ming Wei, Guo Li, Yilong Zhao, Xiuzhen Yan, Shukai Wang, Xuezheng Song, Zhongfu Wang, Linjuan Huang.  (2025)  Isolation, structural characterization of natural chondroitin sulfate oligosaccharides and their binding study with anti-angiogenic factors.  CARBOHYDRATE POLYMERS,      [PMID:39914977] [10.1016/j.carbpol.2025.123262]

43. Yanyan Wang, Ruyu Yan, Hai Yang, Ying Liu, Xiupeng Zhong, Sa Liu, Renjian Xie, Li Ren.  (2024)  Modular microgel-based bioassembly scaffold induced chondrogenic and osteogenic differentiation of BMSCs.  MACROMOLECULAR BIOSCIENCE,      [PMID:38663437] [10.1002/mabi.202400051]

44. Chenci Xu, Weiqi Li, Jing Mao, Ziyang Liu, An Lao, Lixia Mao, Anqi Gu, Jiaqing Wu, Aili Shen, Kaili Lin, Jiaqiang Liu.  (2024)  Using chondroitin sulfate lithium hydrogel for diabetic bone regeneration via regulation of macrophage polarization.  CARBOHYDRATE POLYMERS,      [PMID:39487003] [10.1016/j.carbpol.2024.122787]

45. Zhang Hugang, Jia Jiaxin, Liu Hanyu, Han Haobo, Li Quanshun.  (2025)  Near-infrared light-driven metabolic reprogramming of synoviocytes for the treatment of rheumatoid arthritis.  Nature Communications,  16  (1): (1-21).  [PMID:40676021] [10.1038/s41467-025-61923-7]

46. Xinyi Zhou, Siyu Fang, Luoyan Lin, Hao Feng, Tianyu Li, Lu Fang.  (2025)  Development of an electrochemical sensor for heparin utilizing PEDOT:PSS/AuNPs nanocomposites.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.114480]

47. Zuwu Tang, Meiqiong Yu, Ajoy Kanti Mondal, Xinxing Lin.  (2023)  Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels.  Polymers,  15  (2): (271).  [PMID:36679152] [10.3390/polym15020271]

48. Liu Jinshui, Liu Guoning, Zang Lingjie, Liu Wenxiu.  (2014)  Calcein-functionalized Fe3O4@SiO2 nanoparticles as a reusable fluorescent nanoprobe for copper(II) ion.  MICROCHIMICA ACTA,  182  (3): (547-555).  [PMID:] [10.1007/s00604-014-1358-7]

49. Qinying Yan, Shulin Shen, Linxiao Liu, Jiaqi Weng, Gensuo Zheng, Xu Dong, Jing Yang, Qingliang Yang, Jing Xie.  (2024)  Fabrication of controlled porous and ultrafast dissolution porous microneedles by organic-solvent-free ice templating method.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:38734274] [10.1016/j.ijpharm.2024.124220]

50. Wuxia Zhang, Feifei Sun, Hong Niu, Qingjie Wang, Jinyou Duan.  (2015)  Mechanistic insights into cellular immunity of chondroitin sulfate A and its zwitterionic N-deacetylated derivatives.  CARBOHYDRATE POLYMERS,      [PMID:25843866] [10.1016/j.carbpol.2015.01.059]

51. Wenyan Gao, Shaochun Li, Ya Miao, Guangfu Yuan, Gaoyang Li, Guoqiang Zhou, Guang Jia, Xinjian Yang, Yi Jin.  (2025)  Selenium nanozyme-crosslinked composite hydrogel for promoting cartilage regeneration in osteoarthritis via an integrated ‘outside-in’ and ‘inside-out’ strategy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:40252578] [10.1016/j.jcis.2025.137612]

52. Jian Yang, Jiale Jin, Haojie Yu, Yun Wang, Li Wang, Xiaowei Liu, Dongyu Wang, Yudi Huang, Chenguang Ouyang, Yu Wang, Yichuan Hong, Shuning Ren, Jian Hu, Jingyi Feng.  (2025)  Dopamine-functionalized chondroitin sulfate/gelatin-based composite hydrogels for enhancing wound healing and bone regeneration.  CARBOHYDRATE POLYMERS,      [PMID:40733772] [10.1016/j.carbpol.2025.123809]

53. Yishan Chen, Wei Sun, Ya Wen, Xiaozhao Wang, Jiachen Li, Shaofang Xie, Rui Li, Yuanzhu Ma, Hongwei Wu, Qiuwen Zhu, Ziheng Chen, Xianzhu Zhang, Youguo Liao, Junxin Lin, Wenyue Li, Yiyang Yan, Dingchao Ying, Qiulin He, Hongxu Meng, Chong Teng, Wenyan Zhou, Yong Wang, Xu Li, Zi Yin, Wei Wei, Kam W. Leong, Hongwei Ouyang.  (2025)  A cationic polymer drives glycosaminoglycan assembly and secretion for preclinical osteoarthritis therapy.  Science Translational Medicine,  17  (804):   [PMID:40561002] [10.1126/scitranslmed.adl5623]

54. Shulin Shen, Yuxin Liu, Liting Wang, Jiaqi Weng, Binghui Xie, Yueyue Xie, Xuechao Chen, Qingqing Huo, Xiaohe Chu, Yunxiang Zhang, Meselhy R. Meselhy Zayed, Qinying Yan.  (2025)  Achieving rapid and precisely controllable drug loading via spontaneous imbibition in porous microneedles: mechanistic and optimization strategies.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:41325831] [10.1016/j.ijpharm.2025.126430]

55. Yansong Wang, Yichong He, Yuxun Wu, Enze Zhao, Hanwei Huang, Zhengbin Yan, Hainan Shen, Fenbo Ma, ShuaiShuai Cao, Bin Tang.  (2026)  A Novel Polyetheretherketone–Chondroitin Sulfate Zinc Composite: Enhancing Osseointegration through the Synergistic Effects of Chondroitin Sulfate and Zinc for Advanced Dental Implant Applications.  ACS Biomaterials Science & Engineering,      [PMID:41507113] [10.1021/acsbiomaterials.5c01189]