Collagen I, rat tail (3-4 mg/ml) - 3-4 mg / ml in 0.02 N acetic acid , CAS No.C390612

CAS: C390612 Cat. No.: C390612

GRADE & PURITY 3-4 mg / ml in 0.02 N acetic acid

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

In humans, type I collagen is the most abundant and broadly expressed collagen. This heterotrimer contains two alpha 1 (I) chains and one alpha 2 (I) chain. Collagen type I α 1 (COL1A1), a major component of collagen type I, codes for pro-α 1 chains of type I collagen. It has repeating Gly-Xaa-Yaa tri-peptides motifs. The collagen alpha-1(I) chain protein is a member of the collagen complex superfamily. COL1A1 has a von Willebrand factor type C (vWFC) domain, a collagen triple-helix repeat, and a fibrillar collagen C-terminal domain (COLF).

Product description

Collagen I, rat tail, （100mg), is used either as a thin layer on tissue-culture surfaces to enhance cell attachment and proliferation, or as a gel to promote expression of cell-specific morphology and function.

Product application

Collagen Type I, rat tail has been used:

for collagen 3D proliferation assays

for atelocollagen proliferation assays

in a comparative study to make microcapsules for templating on mesoporous cores of pure vaterite calcium carbonate (CaCO3) crystals to evaluate the structure-property relationship

in coverslip coating to grow the human cerebral microvascular endothelial cell line (hCMEC/D3) for creating a cell coculture and chronic subdural hematoma (CSDH) patient hematoma sample induced injury model

Specifications

Specifications & Purity

3-4 mg / ml in 0.02 N acetic acid

Biochemical and Physiological Mechanisms

Collagen type I α 1 (COL1A1) plays a key role in chemoresistance and may act as a therapeutic target. It is involved in carboplatin-resistant ovarian cancer (OV). COL1A1 serves as an oncogene in the development of colorectal cancer (CRC). Dominant inherit

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.