Dacarbazine (NSC-45388) - Moligand™, 10mM in DMSO , CAS No.4342-03-4

CAS: 4342-03-4 Cat. No.: D408297 Molecular Weight: 182.18 EC Number: 224-396-1

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

DTIC-Dome, Imidazole Carboxamide | 5-​(3,​3-​dimethyl-​1-​triazen-​1-​yl)​-1H-​imidazole-​4-​carboxamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Dacarbazine (NSC-45388) Dacarbazine (NSC-45388, DTIC-Dome, Imidazole Carboxamide) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA functi
In vitro

Treatment of Dacarbazine sensitizes melanomas to lysis of peptide-specific CTL and it is is mediated through Fas-independent pathway.

In vivo

Treatment of combination of Axitinib and DTIC demonstrates significant antitumor activity against melanoma flank xenografts, reduces tumor cell proliferation and decreases the area of tumor necrosis and increases apoptosis. It also reduces meta-tasis-related factors and prolongs lifespan in mice.
Cell Data

cell lines：

Concentrations：20 μM

Incubation Time：48 h

Powder Purity:≥99%

Specifications

Synonyms

DTIC-Dome, Imidazole Carboxamide | 5-​(3, ​3-​dimethyl-​1-​triazen-​1-​yl)​-1H-​imidazole-​4-​carboxamide

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Dacarbazine (NSC-45388, DTIC-Dome, Imidazole Carboxamide) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Product Properties

• ALogP: -0.6

Names and Identifiers

• Isomeric SMILES: CN(C)/N=N/C1=C(NC=N1)C(=O)N
• RTECS: NI3950000
• Molecular Weight: 182.18
• Reaxy-Rn: 958638
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=958638&ln=

Associated Targets(Human)

MMP9 Tchem Matrix metalloproteinase-9 (1 Activities)

Discover Target: MMP9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 255°C

References

1. Pan Li, Chun Hui Liu, Yan Yan Zhao, Da Dong Cao, Bo Zhi Chen, Xin Dong Guo, Weifen Zhang.  (2023)  Multifunctional Covalent Organic Framework-Based Microneedle Patch for Melanoma Treatment.  BIOMACROMOLECULES,      [PMID:37475132] [10.1021/acs.biomac.3c00488]

2. Jingyi Zhu, Xiangning Li, Wenling Gao, Jian Jing.  (2023)  Integrin Targeting Enhances the Antimelanoma Effect of Annexin V in Mice.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (4): (3859).  [PMID:36835282] [10.3390/ijms24043859]

3. Jia Li, Bo-Xiang Wang, De-Hong Cheng, Yue Zhang, Qiang Yao, Xin-bin Ji, Jing Guo, Yan-Hua Lu.  (2022)  An Eco-Friendly Antheraea Pernyi Silk Gland Protein/Sodium Alginate Multiple Network Hydrogel as Potential Drug Release Systems.  Gels,  9  (1): (4).  [PMID:36661772] [10.3390/gels9010004]

4. Bei Bei Zhou, Dan Liu, Jia Cheng Qian, Ren Xiang Tan.  (2022)  Vegetable-derived indole enhances the melanoma-treating efficacy of chemotherapeutics.  PHYTOTHERAPY RESEARCH,  36  (11): (4278-4292).  [PMID:35883268] [10.1002/ptr.7565]

5. Dong Zhang, Weifen Zhang, Xinghan Wu, Qian Li, Zhiyi Mu, Fengshuo Sun, Mogen Zhang, Guoyan Liu, Linlin Hu.  (2021)  Dual Modal Imaging-Guided Drug Delivery System for Combined Chemo-Photothermal Melanoma Therapy.  International Journal of Nanomedicine,      [PMID:34045853] [10.2147/IJN.S306269]

6. Yupeng Bi, Longlong Li, Jin Liu, Yao Wang, Boying Wang, Yanxin Wang, Christopher D. Snow, Jun Li, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang.  (2024)  Smart Cancer-Targeting and Super-Sensitive Sensing of Eu3+/Tb3+-Induced Hyaluronan Characteristic Nano-Micelles with Effective Drug Loading and Release.  MOLECULES,  29  (21): (5070).  [PMID:39519711] [10.3390/molecules29215070]