Fludrocortisone-d5 - Moligand™ , CAS No.127-31-1(unlabeled)

CAS: 127-31-1(unlabeled) Cat. No.: F336062 Molecular Weight: 385.48 EC Number: 204-833-2 PubChem CID: 46781595

GRADE & PURITY Moligand™

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Fludrocortisone-d5 is a labeled mineralcorticoid which can increase plasma fluid retention and volume. Structurally Fludrocortisone-d5 is identical to cortisol at every position except one hydrogen is replaced with a fluorine. Studies suggest that Fludrocortisone-d5 may sensitize vascular receptors to pressor amines. It has been observed that mineralcorticoids can increase the intracellular sodium concentration and decrease intracellular potassium. These studies suggest that Fludrocortisone-d5 alters the properties of adrenergic receptors as a result of a shift in intracellular cations.

Specifications

Specifications & Purity

Moligand™

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Canonical Smiles: [2H]C1=C2CC[C@H]3C4CCC([C@H]4(C[C@@H](C3([C@H]2(CC(C1=O)([2H])[2H])C)F)O)C)(C(=O)C([2H])([2H])O)O
• Isomeric SMILES: [2H]C1=C2CC[C@H]3C4CCC([C@]4(C[C@@H](C3([C@]2(CC(C1=O)([2H])[2H])C)F)O)C)(C(=O)C([2H])([2H])O)O
• PubChem CID: 46781595
• Molecular Weight: 385.48

Associated Targets(Human)

NR3C2 Tclin Mineralocorticoid receptor (1 Activities)

Discover Target: NR3C2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Soluble in DMSO and Methanol
• Melt Point(°C): 238-240°C (lit.)(dec.)