≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Gboxin Gboxin is an inhibitor of oxidative phosphorylation in cancer cells. Gboxin inhibits the activity of F0F1 ATP synthase . It specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.
Targets
oxidative phosphorylation ; F0F1 ATP synthase
In vitro
Gboxin rapidly and irreversibly compromises GBM oxygen consumption. Reliant on its positive charge, Gboxin associates with mitochondrial oxidative phosphorylation complexes in a proton gradient dependent manner and inhibits F0F1 ATP synthase activity. Gboxin targets unique features of mitochondrial pH in GBM and other cancer cells, independent of their genetic composition, and exerts its tumor cell specific toxicity in primary culture and in vivo.
Cell Research(from reference)
Cell lines：HTS, MEF and astrocyte cells
Concentrations：0-15 μM
Incubation Time：96 h
| ALogP | 3.086 |
|---|---|
| hba_count | 2 |
| Rotatable Bond | 6 |
| Pubchem Sid | 488203025 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488203025 |
| Canonical Smiles | CCC1=[N+](C2=CC=CC=C2N1CC(=O)OC3CC(CCC3C(C)C)C)C.[Cl-] |
| IUPAC Name | [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 2-(2-ethyl-3-methylbenzimidazol-3-ium-1-yl)acetate;chloride |
| InChIKey | UBWVTCCKVGOTBG-VYZBTARASA-M |
| INCHI | 1S/C22H33N2O2.ClH/c1-6-21-23(5)18-9-7-8-10-19(18)24(21)14-22(25)26-20-13-16(4)11-12-17(20)15(2)3;/h7-10,15-17,20H,6,11-14H2,1-5H3;1H/q+1;/p-1/t16-,17+,20-;/m1./s1 |
| Isomeric SMILES | CCC1=[N+](C2=CC=CC=C2N1CC(=O)O[C@@H]3C[C@@H](CC[C@H]3C(C)C)C)C.[Cl-] |
| Molecular Weight | 392.96 |
| Reaxy-Rn | 31744812 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31744812&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Amino acids and derivatives - Alpha amino acids and derivatives |
| Direct Parent | Alpha amino acid esters |
| Alternative Parents | Menthane monoterpenoids Bicyclic monoterpenoids Aromatic monoterpenoids Benzimidazoles N-substituted imidazoles Benzenoids Imidazolines Heteroaromatic compounds Carboxylic acid esters Propargyl-type 1,3-dipolar organic compounds Monocarboxylic acids and derivatives Carboximidamides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organic oxides Organic chloride salts Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Alpha-amino acid ester - P-menthane monoterpenoid - Monoterpenoid - Bicyclic monoterpenoid - Aromatic monoterpenoid - Benzimidazole - Benzenoid - N-substituted imidazole - Heteroaromatic compound - 2-imidazoline - Azole - Carboxylic acid ester - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Monocarboxylic acid or derivatives - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic chloride salt - Organic salt - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as alpha amino acid esters. These are ester derivatives of alpha amino acids. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 D2314734 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| D2314751 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| D2314752 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| D2314753 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| D2314766 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| D2314776 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| D2314783 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| D2314786 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| D2314787 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| D2314790 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| D2314791 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| D2314806 | Certificate of Analysis | Jan 21, 2026 | G414204 |
| Solubility | Solubility (25°C) In vitro Ethanol: 79 mg/mL (201.03 mM); DMSO: 39 mg/mL (99.24 mM); Water: 2 mg/mL (5.08 mM); |
|---|---|
| Sensitivity | Moisture sensitive |
| DMSO(mg / mL) Max Solubility | 39 |
| DMSO(mM) Max Solubility | 99.2467426710098 |
| Water(mg / mL) Max Solubility | 2 |
| Water(mM) Max Solubility | 5.08957654723127 |
| Molecular Weight | 393.000 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 6 |
| Exact Mass | 392.223 Da |
| Monoisotopic Mass | 392.223 Da |
| Topological Polar Surface Area | 35.100 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 481.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 3 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
