GLUT inhibitor-1 - ≥98% , CAS No.2421141-40-2

CAS: 2421141-40-2 Cat. No.: G647738 Molecular Weight: 549.67

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3 , with IC 50 s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases

In Vivo

Summary of the pharmacokinetic parameters of GLUT inhibitor-1 (compound 15b; 30 mg/kg) in mouse and rat . Parameter Mouse Rat oral C max (ng/mL) 2525 1675 oral AUC (ng/mL) 5890 6813 CL (mL/min/kg) 40 37 V dss (L/Kg) 1.70 4.51 t 1/2 (h) 0.785 2.59 F (%) 45.4 49.4 B/P b 0.05 b: Solubility is determined in PBS buffer solutions. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:GLUT1 242 nM (IC 50 ) GLUT3 179 nM (IC 50 )

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3 , with IC 50 s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Molecular Weight: 549.67

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (181.93 mM; ultrasonic and warming and heat to 60°C)