10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts
In Vitro
Glutaminase C-IN-1 (Compound 968) (10 μM; 14 d) inhibits cellular transformation in NIH 3T3 cells. ?\nGlutaminase C-IN-1 (10 μM; 6 d) blocks the signaling activity of a specific target of Dbl. ?\nGlutaminase C-IN-1 blocks the transforming activity of human breast cancer cells. ?\nGlutaminase C-IN-1 (10 μM) blocks glutaminolysis in transformed cells. ?\nGlutaminase C-IN-1 preferentially binds to the monomeric state of Glutaminase C. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MDA-MB231 cells, SKBR3 cells, and NIH 3T3 cells Concentration: 10 μM Incubation Time: 5 h Result: Inhibited cell growth.
In Vivo
Glutaminase C-IN-1 (Compound 968) (200 μg/mouse; i.p.; daily for 12 days) reduces tumor volume in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: SCID mice with P493 B lymphoma cells Dosage: 200 μg/mouse Administration: Intraperitoneal injection, daily for 12 days Result: Caused a ~50% reduction in the size of the tumors.
IC50& Target:Glutaminase C
| Isomeric SMILES | CC1(CC2=C(C(NC3=C2C4=CC=CC=C4C=C3)C5=CC(=C(C=C5)N(C)C)Br)C(=O)C1)C |
|---|---|
| PubChem CID | 3099980 |
| Molecular Weight | 475.4 |
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