Glycyl-L-phenylalanine - ≥98% , CAS No.3321-03-7

CAS: 3321-03-7 Cat. No.: G121421 Molecular Weight: 222.24 Beilstein Registry Number: 2279318

GRADE & PURITY ≥98%

Synonyms

G0136 | T72314 | (S)-2-(2-Aminoacetamido)-3-phenylpropanoicacid | N-Glycyl-3-phenylalanine | SCHEMBL232699 | (S)-2-(2-Aminoacetamido)-3-phenylpropanoic acid | (S)-2-(2-Amino-acetylamino)-3-phenyl-propionic acid | AKOS010366203 | CHEBI:73912 | Glycylphenyl

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

G0136 | T72314 | (S)-2-(2-Aminoacetamido)-3-phenylpropanoicacid | N-Glycyl-3-phenylalanine | SCHEMBL232699 | (S)-2-(2-Aminoacetamido)-3-phenylpropanoic acid | (S)-2-(2-Amino-acetylamino)-3-phenyl-propionic acid | AKOS010366203 | CHEBI:73912 | Glycylphenyl

Specifications & Purity

≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504756153
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504756153
• Canonical Smiles: C1=CC=C(C=C1)CC(C(=O)O)NC(=O)CN
• IUPAC Name: (2S)-2-[(2-aminoacetyl)amino]-3-phenylpropanoic acid
• InChIKey: JBCLFWXMTIKCCB-VIFPVBQESA-N
• INCHI: 1S/C11H14N2O3/c12-7-10(14)13-9(11(15)16)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,14)(H,15,16)/t9-/m0/s1
• Isomeric SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)CN
• WGK Germany: 3
• Molecular Weight: 222.24
• Beilstein: 2279318
• Reaxy-Rn: 2124348
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2124348&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Not available
• Direct Parent: Peptides
• Alternative Parents: Phenylalanine and derivatives N-acyl-alpha amino acids Phenylpropanoic acids Amphetamines and derivatives Amino acids Propargyl-type 1,3-dipolar organic compounds Monocarboxylic acids and derivatives Carboxylic acids Carboximidic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Alpha peptide - Phenylalanine or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - 3-phenylpropanoic-acid - Alpha-amino acid or derivatives - Amphetamine or derivatives - Monocyclic benzene moiety - Benzenoid - Amino acid or derivatives - Amino acid - Carboximidic acid - Carboximidic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organopnictogen compound - Primary aliphatic amine - Organic oxygen compound - Amine - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Organic oxide - Primary amine - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
• External Descriptors: dipeptide

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ACE Tclin Angiotensin-converting enzyme (1423 Activities)

Discover Target: ACE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC15A1 Tchem Oligopeptide transporter small intestine isoform (922 Activities)

Discover Target: SLC15A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC15A2 Tchem Solute carrier family 15 member 2 (186 Activities)

Discover Target: SLC15A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Tpp2 Tripeptidyl aminopeptidase (141 Activities)

Discover Target: Tpp2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc15a2 Oligopeptide transporter, kidney isoform (114 Activities)

Discover Target: Slc15a2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc15a1 Solute carrier family 15 member 1 (124 Activities)

Discover Target: Slc15a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: heat sensitive
• Specific Rotation[α]: 41° (C=2,H2O)
• Molecular Weight: 222.240 g/mol
• XLogP3: -2.700
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 222.1 Da
• Monoisotopic Mass: 222.1 Da
• Topological Polar Surface Area: 92.400 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 250.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Chusheng Liu, Haibin Li, Qiqin Wang, Jacques Crommen, Haibo Zhou, Zhengjin Jiang.  (2017)  Preparation and evaluation of 400 μm I.D. polymer-based hydrophilic interaction chromatography monolithic columns with high column efficiency.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:28629939] [10.1016/j.chroma.2017.06.034]

2. Hongkai Xie, Wenhua Ji, Dahui Liu, Wei Liu, Daijie Wang, Ruimin Lv, Xiao Wang.  (2015)  Surface molecularly imprinted polymers with dummy templates for the separation of dencichine from Panax notoginseng.  RSC Advances,  5  (60): (48885-48892).  [PMID:] [10.1039/C5RA06749A]