GNE-502 - ≥99% , CAS No.1953134-16-1

CAS: 1953134-16-1 Cat. No.: G648176 Molecular Weight: 471.59

GRADE & PURITY ≥99%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

GNE-502 is an orally active and potent degrader for estrogen receptor ( ER ). GNE-502 can be used for the research of breast cancer

In Vivo

GNE-502 (10 and 100 mg/kg; p.o.) possesses sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model . GNE-502 shows dose dependent tumor growth inhibition at 10 mg/kg and 30 mg/kg, with tumor stasis at 100 mg/kg . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mouse Dosage: 10 and 100 mg/kg (Pharmacokinetic Analysis) Administration: p.o.; single dosage Result: Possessed sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model.

Form:Solid

IC50& Target:ER

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

GNE-502 is an orally active and potent degrader for estrogen receptor ( ER ). GNE-502 can be used for the research of breast cancer.

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 471.59

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (212.05 mM; Need ultrasonic)