Heliquinomycin - ≥80% , CAS No.178182-49-5

CAS: 178182-49-5 Cat. No.: H275011 Molecular Weight: 698.58

COA

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Heliquinomycin - ≥80% CAS No(178182-49-5) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥80%

Synonyms

DTXSID00939048 | Heliquinomycin | Methyl 3'-[(2,6-dideoxy-3-O-methylhexopyranosyl)oxy]-3,4',9',10-tetrahydroxy-7'-methoxy-5',8',9-trioxo-4,5',8',9-tetrahydro-3H,3'H-spiro[benzo[1,2-b:5,4-c']dipyran-2,2'-naphtho[2,3-b]furan]-7-carboxylate | NSC702208 | NSC

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥80% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μ M) that can inhibit the synthesis of DNA and RNA. Heliquinomycin has effective antibacterial activity against Gram positive bacterial strains. Heliquinomycin can inhibit the growth of cancer cells.

Specifications

Synonyms

DTXSID00939048 | Heliquinomycin | Methyl 3'-[(2, 6-dideoxy-3-O-methylhexopyranosyl)oxy]-3, 4', 9', 10-tetrahydroxy-7'-methoxy-5', 8', 9-trioxo-4, 5', 8', 9-tetrahydro-3H, 3'H-spiro[benzo[1, 2-b:5, 4-c']dipyran-2, 2'-naphtho[2, 3-b]furan]-7-carboxylate | NSC702208 | NSC

Specifications & Purity

≥80%

Biochemical and Physiological Mechanisms

Antibiotic agent. DNA helicase inhibitor (IC 50 values are 4.3 and 2.5 μM for DNA helicase B and MCM4/6/7 helicase respectively). Inhibits DNA replication (IC 50 values are 1 - 4 μM). Weak topoisomerase I and II inhibitor. Inhibits DNA and RNA synthesis.

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥80%

Names and Identifiers

Canonical Smiles	CC1C(C(CC(O1)OC2C3=C(C4=C(C(=C3OC25C(CC6=C(O5)C(=C7C(=C6)C=C(OC7=O)C(=O)OC)O)O)O)C(=O)C(=CC4=O)OC)O)OC)O
IUPAC Name	methyl (2R,3R,3'R)-3,4',9',10-tetrahydroxy-3'-(5-hydroxy-4-methoxy-6-methyloxan-2-yl)oxy-7'-methoxy-5',8',9-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2'-3H-benzo[f][1]benzofuran]-7-carboxylate
InChIKey	MLFZQFHGXSVTGX-VJANPNJTSA-N
INCHI	1S/C33H30O17/c1-10-23(36)15(44-3)9-18(46-10)48-30-22-25(38)20-13(34)8-14(43-2)24(37)21(20)27(40)29(22)50-33(30)17(35)7-12-5-11-6-16(31(41)45-4)47-32(42)19(11)26(39)28(12)49-33/h5-6,8,10,15,17-18,23,30,35-36,38-40H,7,9H2,1-4H3/t10?,15?,17-,18?,23?,30-,33-/m1/s1
Isomeric SMILES	CC1C(C(CC(O1)O[C@@H]2C3=C(C4=C(C(=C3O[C@]25[C@@H](CC6=C(O5)C(=C7C(=C6)C=C(OC7=O)C(=O)OC)O)O)O)C(=O)C(=CC4=O)OC)O)OC)O
Molecular Weight	698.58
Reaxy-Rn	7616689
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7616689&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Benzopyrans
    - Subclass 1-benzopyrans

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Benzopyrans
Subclass	1-benzopyrans
Intermediate Tree Nodes	Not available
Direct Parent	Pyranochromenes
Alternative Parents	Naphthofurans Hexoses Naphthoquinones Isocoumarins and derivatives O-glycosyl compounds 2-benzopyrans Coumarans Aryl ketones Quinones 1-hydroxy-4-unsubstituted benzenoids Pyranones and derivatives Ketals Oxanes Vinylogous esters Vinylogous acids Heteroaromatic compounds Methyl esters Lactones Secondary alcohols Oxacyclic compounds Dialkyl ethers Polyols Monocarboxylic acids and derivatives Hydrocarbon derivatives Aldehydes Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Pyranochromene - Naphthofuran - Hexose monosaccharide - Naphthoquinone - Glycosyl compound - Isocoumarin - O-glycosyl compound - Naphthalene - 2-benzopyran - Coumaran - Quinone - Aryl ketone - Pyranone - 1-hydroxy-4-unsubstituted benzenoid - Ketal - Benzenoid - Pyran - Oxane - Monosaccharide - Vinylogous acid - Methyl ester - Vinylogous ester - Heteroaromatic compound - Secondary alcohol - Carboxylic acid ester - Ketone - Lactone - Acetal - Carboxylic acid derivative - Polyol - Dialkyl ether - Ether - Oxacycle - Monocarboxylic acid or derivatives - Alcohol - Organooxygen compound - Organic oxygen compound - Aldehyde - Hydrocarbon derivative - Organic oxide - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as pyranochromenes. These are organic heterocyclic compounds containing a pyran ring fused to a chromene (1-benzopyran) moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

A498 (42825 Activities)

Solubility	Soluble in ethanol and in DMSO
Molecular Weight	698.600 g/mol
XLogP3	2.600
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	6
Exact Mass	698.148 Da
Monoisotopic Mass	698.148 Da
Topological Polar Surface Area	243.000 Å²
Heavy Atom Count	50
Formal Charge	0
Complexity	1480.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	4
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Heliquinomycin - ≥80% , CAS No.178182-49-5

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

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