IFN alpha-IFNAR-IN-1 , CAS No.844882-93-5

CAS: 844882-93-5 Cat. No.: I1434777 Molecular Weight: 279.4 PubChem CID: 826634

Storage

Store at -20°C

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Overview

IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR ; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).IC50 value:Target: IFN alpha-IFNAR interaction inhibitorIFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α.

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Product Properties

• ALogP: 4.6

Names and Identifiers

• Canonical Smiles: CNCC1=CC=CC=C1SC2=CC=CC3=CC=CC=C32
• IUPAC Name: N-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine
• InChIKey: OHDXDNUPVVYWOV-UHFFFAOYSA-N
• INCHI: 1S/C18H17NS/c1-19-13-15-8-3-5-11-17(15)20-18-12-6-9-14-7-2-4-10-16(14)18/h2-12,19H,13H2,1H3
• Isomeric SMILES: CNCC1=CC=CC=C1SC2=CC=CC3=CC=CC=C32
• PubChem CID: 826634
• Molecular Weight: 279.4

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organosulfur compounds
    • Class Thioethers
      • Subclass Aryl thioethers

• Kingdom: Organic compounds
• Superclass: Organosulfur compounds
• Class: Thioethers
• Subclass: Aryl thioethers
• Intermediate Tree Nodes: Not available
• Direct Parent: Diarylthioethers
• Alternative Parents: Naphthalenes Thiophenol ethers Phenylmethylamines Benzylamines Aralkylamines Sulfenyl compounds Dialkylamines Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Diarylthioether - Naphthalene - Benzylamine - Phenylmethylamine - Thiophenol ether - Aralkylamine - Monocyclic benzene moiety - Benzenoid - Secondary aliphatic amine - Sulfenyl compound - Secondary amine - Hydrocarbon derivative - Amine - Organopnictogen compound - Organonitrogen compound - Organic nitrogen compound - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as diarylthioethers. These are organosulfur compounds containing a thioether group that is substituted by two aryl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y