IKKγ NBD Inhibitory Peptide TFA, CAS No.I659065

CAS: I659065 Cat. No.: I659065 Molecular Weight: 3807.32

GRADE & PURITY ≥99%

Overview

IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKK

Appearance:Solid

In Vitro:In a canonical pathway, NF kappa B activation depends on the IKK complex activity, which is formed by three subunits (IKKκ and IKKβ and IKKγ/NEMO), thus the KKγ NBD Inhibitory Peptide TFA inhibits TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory P

In Vivo:IKKγ NBD Inhibitory Peptide TFA (40 μg/4 μL; ICV; single dose; 2 h before MCAO) exhibits neuroprotective effect with reduction in DNA fragmentation, and its ischemic brain damage reduction mechanism be attributed to reduction in inflammation following isc

Biological Activity:IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKK

Specifications

Product Name

IKKγ NBD Inhibitory Peptide TFA, CAS No.I659065

Specifications & Purity

≥99%

CAS

I659065

Molecule Type

Peptide

Storage and Shipping

Storage

Desiccated,Store at -80°C

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Dry ice packs + Cold packs