10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 49 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Isoniazid Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG , used for the prevention and treatment of tuberculosis.
In vitro
In vivo
Isoniazid increases CYP2E1 protein, and the 6-hydroxychlorzoxazone formation rate is increased by 2.7 and 2.2-fold in liver and kidney, respectively. Isoniazid decreases liver and kidney 20-HETE content to 34% and 15.6% of control, respectively, without significantly altering tissue 19-HETE concentration.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| ALogP | -0.7 |
|---|
| Isomeric SMILES | C1=CN=CC=C1C(=O)NN |
|---|---|
| WGK Germany | 3 |
| RTECS | NS1751850 |
| Molecular Weight | 137.14 |
| Beilstein | 119374 |
| Reaxy-Rn | 119374 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=119374&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | 171.4°C |
|---|
| 1. Fang Li, Min Zhu, Zimu Li, Nuotong Shen, Hao Peng, Bing Li, Jianbo He. (2023) Machine learning assisted discrimination and detection of antibiotics by using multicolor microfluidic chemiluminescence detection chip. TALANTA, [PMID:38043343] [10.1016/j.talanta.2023.125446] |
| 2. Jiawang Xiang, Bing Zhang, Yani Shi, Yanfei Wen, Yuan Yuan, Jianying Lin, Zhihuan Zhao, Jing Li, Yan Cheng. (2023) Isoniazide modified Ag nanoparticles triggered photothermal immunoassay for carcinoembryonic antigen detection. ANALYTICAL BIOCHEMISTRY, [PMID:37890548] [10.1016/j.ab.2023.115370] |
| 3. Yangguang Zhu, Xiufen Li, Mengfan Wu, Mingjiao Shi, Qichen Tian, Li Fu, Hsu-Sheng Tsai, Wan-Feng Xie, Guosong Lai, Gang Wang, Nan Jiang, Chen Ye, Cheng-Te Lin. (2023) A novel electrochemical aptasensor based on eco-friendly synthesized titanium dioxide nanosheets and polyethyleneimine grafted reduced graphene oxide for ultrasensitive and selective detection of ciprofloxacin. ANALYTICA CHIMICA ACTA, [PMID:37524471] [10.1016/j.aca.2023.341607] |
| 4. Jing-yi Jiang, Qingyi Li, Wen-chang Wang, Xiao-hui Chen, Zhi-dong Chen. (2023) A Novel Electrochemiluminescence Modified Glasss Carbon Electrode Based on Carboxylated Acetylene Black / Ru(bpy)32+ / Nafion for Detection of Isoniazid. International Journal of Electrochemical Science, [PMID:] [10.20964/2018.01.76] |
| 5. Zhiyong Zheng, Yuehua Deng, Weining Xie, Sirui Chen, Xiaoxiao Liang, Shiyuan Liu, Yanbin Jiang, Huaiyu Yang. (2023) Co-Former Screening Method for Multicomponent Crystals Based on Partial Least Squares Regression: A Case Study of Ciprofloxacin. CRYSTAL GROWTH & DESIGN, [PMID:] [10.1021/acs.cgd.2c01414] |
| 6. Keren Shi, Xiangming Liang, Mingming Li, Zhenhua Zhai, Ying Liu, Xiaoyan Shan, Yang Ma, Qianqian Gan, Huiqin Yao. (2023) Construction of isoniazid pharmaceutical logic system based on poly(N, N-diethylacrylamide) hydrogel films. Sensors and Actuators Reports, [PMID:] [10.1016/j.snr.2023.100147] |
| 7. Ruiming Chen, Tingting Hu, Shu Xing, Tao Wei, Jianbin Chen, Tianduo Li, Qingfen Niu, Zhengyang Zhang, Huijun Ren, Xiaoxu Qin. (2022) A dual-responsive fluorescent turn-on sensor for sensitively detecting and bioimaging of hydrazine and hypochlorite in biofluids, live-cells, and plants. ANALYTICA CHIMICA ACTA, [PMID:36628730] [10.1016/j.aca.2022.340735] |
| 8. Chan Jin, Jinbo Li, Xiaoguang Yang, Shuang Zhou, Chang Li, Jiang Yu, Zhaomeng Wang, Dun Wang, Zhonggui He, Yiguo Jiang, Yongjun Wang. (2022) Doxorubicin-isoniazid conjugate regulates immune response and tumor microenvironment to enhance cancer therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:36549403] [10.1016/j.ijpharm.2022.122509] |
| 9. Zhimei Wang, Yuehuan Zhang, Qing Chen, Xin Xiao, Carl Redshaw. (2022) Preparation of pelargonic acid vesicles and sustained drug release. Canadian Journal of Chemistry, 101 (2): [PMID:] [10.1139/cjc-2022-0075] |
| 10. Lu-Shuang Li, Ying-Xia Zhang, Wei Gong, Jing Li. (2022) Novel β-cyclodextrin doped carbon dots for host–guest recognition-assisted sensing of isoniazid and cell imaging. RSC Advances, 12 (46): (30104-30112). [PMID:36329931] [10.1039/D2RA05089G] |
| 11. Xianzhi Huang, Ziqiang Zhou, Xiaohua Xiao, Ling Xia, Gongke Li. (2022) Aldehyde spiropyran fluorescent probe for rapid determination of hydrazine in environmental water. LUMINESCENCE, 37 (11): (1891-1898). [PMID:36000442] [10.1002/bio.4369] |
| 12. Jianzhi Huang, Zhixin Qiu, Hao Yang, Chujun Chen, Yanliang Li. (2022) Highly selective simultaneous determination of isoniazid and acetaminophen using black phosphorus nanosheets electrochemical sensor. ELECTROCHIMICA ACTA, [PMID:] [10.1016/j.electacta.2022.140775] |
| 13. Xubin Qian, Kefu Peng, Lei Xu, Shaoyu Tang, Weilai Wang, Min Zhang, Junfeng Niu. (2021) Electrochemical decomposition of PPCPs on hydrophobic Ti/SnO2-Sb/La-PbO2 anodes: Relationship between surface hydrophobicity and decomposition performance. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2021.132309] |
| 14. Liu Yueqi, Li Chenxi, Chen Jia, Han Yufen, Wei Ming, Liu Jun, Yu Xiaomin, Li Fangjun, Hu Ping, Fu Lulu, Liu Yong. (2021) Electrospun high bioavailable rifampicin–isoniazid-polyvinylpyrrolidone fiber membranes. Applied Nanoscience, 11 (8): (2271-2280). [PMID:] [10.1007/s13204-021-01957-7] |
| 15. Huinan Sun, Fangchao Yin, Xuefeng Liu, Ting Jiang, Yaohong Ma, Guangheng Gao, Jianguo Shi, Qiongzheng Hu. (2021) Development of a liquid crystal-based α-glucosidase assay to detect anti-diabetic drugs. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2021.106323] |
| 16. Xiao‑Guang Yang, Yan‑Yu Li, Dong‑Xue Zhao, Wei Cui, Han Li, Xin‑Yu Li, Yu‑Xin Li, Dun Wang. (2021) Repurposing of a monoamine oxidase A inhibitor‑heptamethine carbocyanine dye conjugate for paclitaxel‑resistant non‑small cell lung cancer. ONCOLOGY REPORTS, 45 (3): (1306-1314). [PMID:33650669] [10.3892/or.2021.7950] |
| 17. Liu Xinning, Liu Yuanchang, Zhao Guangjian, Zhang Yidan, Liu Lu, Wang Juan, Wang Yifan, Zhang Siyu, Li Xin, Guo Dongliang, Wang Peng, Xu Ximing. (2021) Biochemical Characterization of Arylamine N-acetyltransferases From Vibrio vulnificus. Frontiers in Microbiology, [PMID:33537010] [10.3389/fmicb.2020.595083] |
| 18. Kuanxia Ma, Lushan Liang, Xie Zhou, Weiguo Tan, Ou Hu, Zuanguang Chen. (2020) A Redox-induced Dual-mode Colorimetric and Fluorometric Method based on N-CDs and MnO2 for Determination of Isoniazid in Tablets and Plasma Samples. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:33161268] [10.1016/j.saa.2020.119097] |
| 19. Ma Cheng, Wu Mingjun, Ye Weifen, Huang Zhengwei, Ma Xiangyu, Wang Wenhao, Wang Wenhua, Huang Ying, Pan Xin, Wu Chuanbin. (2020) Inhalable solid lipid nanoparticles for intracellular tuberculosis infection therapy: macrophage-targeting and pH-sensitive properties. Drug Delivery and Translational Research, 11 (3): (1218-1235). [PMID:32946043] [10.1007/s13346-020-00849-7] |
| 20. Fang Liu, Fu-Bin Jiang, Yan-Tuan Li, Ren-Min Liu, Zhi-Yong Wu, Cui-Wei Yan. (2020) Cocrystallization with syringic acid presents a new opportunity for effectively reducing the hepatotoxicity of isoniazid. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, [PMID:32366135] [10.1080/03639045.2020.1764024] |
| 21. Linsheng Liu, Xianglian Li, Chenrong Huang, Yicong Bian, Xiaoxue Liu, Jun Cao, Wenhao Qu, Liyan Miao. (2020) Bile acids, lipid and purine metabolism involved in hepatotoxicity of first-line anti-tuberculosis drugs. Expert Opinion on Drug Metabolism & Toxicology, [PMID:32436768] [10.1080/17425255.2020.1758060] |
| 22. Fang Liu, Ling-Yang Wang, Ming-Chao Yu, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan. (2020) A new cocrystal of isoniazid-quercetin with hepatoprotective effect: The design, structure, and in vitro/in vivo performance evaluation. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:31945451] [10.1016/j.ejps.2020.105216] |
| 23. Sili Yi, Zhen Lu, Yandai Lin, Jun Wang, Ziwen Qiao, Rongkai Shen, Jin Zhang, Linxi Hou. (2019) A novel mitochondria-targeted phosphorescence probe for hypochlorite ions detection in living cells. TALANTA, [PMID:31892012] [10.1016/j.talanta.2019.120516] |
| 24. Han Xiuyan, Chen Changming, Yan Qiulong, Jia Liqiu, Taj Ayaz, Ma Yufang. (2019) Action of Dicumarol on Glucosamine-1-Phosphate Acetyltransferase of GlmU and Mycobacterium tuberculosis. Frontiers in Microbiology, [PMID:31481936] [10.3389/fmicb.2019.01799] |
| 25. Xiao-Guang Yang, Yan-Hua Mou, Yong-Jun Wang, Jian Wang, Yan-Yu Li, Rui-Heng Kong, Meng Ding, Dun Wang, Chun Guo. (2019) Design, Synthesis, and Evaluation of Monoamine Oxidase A Inhibitors–Indocyanine Dyes Conjugates as Targeted Antitumor Agents. MOLECULES, 24 (7): (1400). [PMID:30974737] [10.3390/molecules24071400] |
| 26. Yumiao Luo, Siqi Chen, Jianle Zhou, Jiamen Chen, Liwen Tian, Wei Gao, Yingyi Zhang, Ande Ma, Liang Li, Zhengzheng Zhou. (2019) Luteolin cocrystals: Characterization, evaluation of solubility, oral bioavailability and theoretical calculation. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.jddst.2019.02.004] |
| 27. Qingzhi Lv, Dun Wang, Zimeng Yang, Jincheng Yang, Ruoshi Zhang, Xiaoguang Yang, Menglin Wang, Yongjun Wang. (2018) Repurposing antitubercular agent isoniazid for treatment of prostate cancer. Biomaterials Science, 7 (1): (296-306). [PMID:30468220] [10.1039/C8BM01189C] |
| 28. Ling-Yu Ruan, Jun-Ting Fan, Wei Hong, He Zhao, Ming-Hui Li, Lei Jiang, Yong-Hong Fu, Yue-Xiao Xing, Cheng Chen, Jun-Song Wang. (2018) Isoniazid-induced hepatotoxicity and neurotoxicity in rats investigated by 1H NMR based metabolomics approach. TOXICOLOGY LETTERS, [PMID:29936297] [10.1016/j.toxlet.2018.05.032] |
| 29. Qingzhi Lv, Xiaoguang Yang, Menglin Wang, Jincheng Yang, Zhilin Qin, Qiming Kan, Haotian Zhang, Yongjun Wang, Dun Wang, Zhonggui He. (2018) Mitochondria-targeted prostate cancer therapy using a near-infrared fluorescence dye–monoamine oxidase A inhibitor conjugate. JOURNAL OF CONTROLLED RELEASE, [PMID:29679664] [10.1016/j.jconrel.2018.04.038] |
| 30. Shi Mo, Ling Jie Li, Hong Qun Luo, Nian Bing Li. (2017) An example of green copper corrosion inhibitors derived from flavor and medicine: Vanillin and isoniazid. JOURNAL OF MOLECULAR LIQUIDS, [PMID:] [10.1016/j.molliq.2017.07.081] |
| 31. Bowan Wu, Lijie Hou, Tiantian Zhang, Yanxia Han, Chao Kong. (2015) A molecularly imprinted electrochemical sensor based on a gold nanoparticle/carbon nanotube hybrid material for the sensitive detection of isoniazid. Analytical Methods, 7 (21): (9121-9129). [PMID:] [10.1039/C5AY01802A] |
| 32. Xiaojing Si, Lin Jiang, Xinyue Wang, Yaping Ding, Liqiang Luo. (2014) Determination of isoniazid content via cysteic acid/graphene modified glassy carbon electrode. Analytical Methods, 7 (2): (793-798). [PMID:] [10.1039/C4AY02013H] |
| 33. Bowan Wu, Zhihua Wang, Zhonghua Xue, Xibin Zhou, Jie Du, Xiuhui Liu, Xiaoquan Lu. (2012) A novel molecularly imprinted electrochemiluminescence sensor for isoniazid detection. ANALYST, 137 (16): (3644-3652). [PMID:22741161] [10.1039/C2AN35499C] |
| 34. Xinchun Li, Zuanguang Chen, Yuwen Zhong, Fan Yang, Jianbin Pan, Yajing Liang. (2011) Cobalt hexacyanoferrate modified multi-walled carbon nanotubes/graphite composite electrode as electrochemical sensor on microfluidic chip. ANALYTICA CHIMICA ACTA, [PMID:22123120] [10.1016/j.aca.2011.10.035] |
| 35. Yao Xu, Xin Tang, Yun Xing, Ziyu Pu, Chengshuang Ling, Qing Yang, Xiaoli Xiong. (2024) 3D hierarchical flowerball-like CoSe2/MnSe nanosheet arrays as a novel electrode for electrochemical sensing of hydrazine. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2024.110504] |
| 36. Chang Tang, Rui Tong, Guoqing Deng, Jing Yang, Yi Zhang, Zhifeng Cai. (2024) Fluorescent carbon dots for highly sensitive diosmetin sensing. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2024.110362] |
| 37. Jinbo Ouyang, Longping Jiang, Jiayao Li, Feiqiang He, Zhi Gao, Mengmeng Wang, Limin Zhou, Zongbo Xie, Zhiqiang Zhu, Yifu Chen. (2025) Light-Driven Crystal Actuation of Fluorinated Acylhydrazones Enabled by [2+2] Photocycloaddition. CHEMISTRY-A EUROPEAN JOURNAL, [PMID:40626992] [10.1002/chem.202501777] |
| 38. Ting Li, Chaoyue Yang, Houkang Cao, Siyi Mo, Bo Li, Zhipeng Huang, Ruobing Zhang, Jianzhao Wu, Kefeng Zhang, Ya Gao. (2023) The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing. MOLECULES, 28 (14): (5496). [PMID:37513369] [10.3390/molecules28145496] |
| 39. Wenzhan Yu, Qian Li, Liqiong He, Renlong Zhou, Lifu Liao, Jinhua Xue, Xilin Xiao. (2023) Green synthesis of CQDs for determination of iron and isoniazid in pharmaceutical formulations. Analytical Methods, 15 (7): (944-950). [PMID:36723197] [10.1039/D2AY01793H] |
| 40. Ruyi Qian, Tongdong Shen, Qiangqiang Yang, Kun-Yi Andrew Lin, Shaoping Tong. (2020) Activation of persulfate by graphite supported CeO2 for isoniazid degradation. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2020.117197] |
| 41. Qin Ju, Zhang Limei, Yang Rui. (2019) Solid pyrolysis synthesis of excitation-independent emission carbon dots and its application to isoniazid detection. JOURNAL OF NANOPARTICLE RESEARCH, 21 (3): (1-11). [PMID:] [10.1007/s11051-019-4503-8] |
| 42. Yu Wu, Yun Huang, Yulan Wang, Xiang Zou, Jun Wang, Weiping Wu. (2018) A regenerable zinc(II) coordination polymer as a dual-luminescent sensor for detection of Cr2O72– and 2,4,6-trinitrophenol in aqueous phase. JOURNAL OF COORDINATION CHEMISTRY, [PMID:] [10.1080/00958972.2018.1536784] |
| 43. Min Xue, Yanchao Lü, Qingqing Sun, Kaiqiang Liu, Zhen Liu, Ping Sun. (2015) Ag(I)-Coordinated Supramolecular Metallogels Based on Schiff Base Ligands: Structural Characterization and Reversible Thixotropic Property. CRYSTAL GROWTH & DESIGN, [PMID:] [10.1021/acs.cgd.5b00952] |
| 44. Zhang Mei, Zhao Jingwen, Long Yingying, Li Changsong, Yang Xiaoming. (2024) Carbon Dots Employed for the Detection of Ranitidine and Elaborating the Detecting Mechanism. JOURNAL OF FLUORESCENCE, [PMID:39269550] [10.1007/s10895-024-03912-5] |
| 45. Jiajia Wang, Yueping Qiu, Lijun Yang, Jincheng Wang, Jie He, Chengwu Tang, Zhaoxu Yang, Wenxiang Hong, Bo Yang, Qiaojun He, Qinjie Weng. (2024) Preserving mitochondrial homeostasis protects against drug-induced liver injury via inducing OPTN (optineurin)-dependent Mitophagy. Autophagy, [PMID:39099169] [10.1080/15548627.2024.2384348] |
| 46. Zhifeng Cai, Guiyu Meng, Yanan Li, Yingjie Zhou. (2024) Sulfur-doped carbon dots derived from cabbage leaves for the determination of alizarin. JOURNAL OF MOLECULAR STRUCTURE, [PMID:] [10.1016/j.molstruc.2024.141247] |
| 47. Chaoyue Yang, Mingli Zhong, Xuefei Jiao, Houkang Cao, Yandan Qin, Hengjie Xu, Fengyue Guo, Zixuan Tang, Tiansong Lv, Lilin Guan, Yongwang Wang, Ya Gao, Kefeng Zhang. (2025) Polysaccharides from Dicliptera chinensis (L.) Juss. Attenuates drug-induced liver injury by phosphorylating AMPK and thus facilitating the entry of FOXO3 into the cell nucleus. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:40239335] [10.1016/j.intimp.2025.114633] |
| 48. Xiaopei Li, Xianxu Chu, Kefan Ying, Xi Chen, Peng Sun, Haiyun Xu, Lu Li, Jie Zhang, Wenjuan Li. (2025) Synthesis of Novel Organic Ni (II) N-isonicotinoylhydrazine-Carbothioamide Complexes and their Application in the Oxygen Evolution Reactions. Inorganic Chemistry Frontiers, [PMID:] [10.1039/D5QI00033E] |
| 49. Qiuhui Zhao, Yaqi Jing, Jiale Zhang, Jiadan Xue, Jianjun Liu, Jianyuan Qin, Zhi Hong, Yong Du. (2025) Polymorphic behavior in isoniazid-4-hydroxybenzoic acid hydrated cocrystals: A combined terahertz, Raman vibrational spectroscopy, and DFT analysis. CHEMICAL PHYSICS, [PMID:] [10.1016/j.chemphys.2025.112999] |
